Synthesis of Novel Symmetrical 14-Disubstituted 123-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation

摘要

A series of symmetric bis-1,2,3-triazole compounds >2–>5(>a–>f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by ¹H-NMR and ¹³C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity of these compounds (AChE inhibition, DPPH and SOD activities) was evaluated. Compound >2f was found to show the highest AChE inhibition activity of all compounds, while compound >3b showed a strong inhibitory effect on DPPH radical and compound >2a was the most effective of all compounds for SOD activity. All synthesized compounds were found to possess moderate antibacterial activity against the bacteria E. coli and Y.pseudotuberculosis.