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Synthesis of Novel Symmetrical 14-Disubstituted 123-Bistriazole Derivatives via ‘Click Chemistry’ and Their Biological Evaluation

机译:通过点击化学合成新型对称的14-二取代的123-双三唑衍生物及其生物学评价

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摘要

A series of symmetric bis-1,2,3-triazole compounds >2–>5(>a–>f) were synthesized as potential antioxidant agents via click chemistry. Their structures were confirmed by 1H-NMR and 13C-NMR. All of the synthesized compounds were subjected to antioxidant and antimicrobial assays. The antioxidant activity of these compounds (AChE inhibition, DPPH and SOD activities) was evaluated. Compound >2f was found to show the highest AChE inhibition activity of all compounds, while compound >3b showed a strong inhibitory effect on DPPH radical and compound >2a was the most effective of all compounds for SOD activity. All synthesized compounds were found to possess moderate antibacterial activity against the bacteria E. coli and Y.pseudotuberculosis.
机译:一系列对称的双1,2,3-三唑化合物> 2 – > 5 (> a – > f )通过点击化学合成了潜在的抗氧化剂。它们的结构通过 1 H-NMR和 13 C-NMR证实。所有合成的化合物均经过抗氧化剂和抗菌测定。评价了这些化合物的抗氧化活性(AChE抑制,DPPH和SOD活性)。发现化合物> 2f 对所有化合物均显示出最高的AChE抑制活性,而化合物> 3b 对DPPH自由基和化合物> 2a 具有较强的抑制作用在所有化合物中对SOD活性最有效。发现所有合成的化合物对细菌大肠杆菌和假结核耶尔森氏菌均具有中等的抗菌活性。

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