Synthesis and Characterization of Some New Cu(II) Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial Antifungal and in Vitro Antileukemia Activity

摘要

Thirty two new Cu(II), Ni(II) and Zn(II) complexes (>1–>32) with salicylidene thiosemicarbazones (>H2L¹–>H2L¹⁰) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new formed compounds was done by ¹H-NMR, ¹³C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex >5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.