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Identification of Gingival Crevicular Fluid Sampling Analytical Methods and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review

机译:牙龈沟液采样分析方法和口腔生物标志物的诊断和监测牙周疾病的鉴定:系统评价

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摘要

Background. Several studies in the last decades have focused on finding a precise method for the diagnosis of periodontal disease in its early stages. Aim. To evaluate from current scientific literature the most common and precise method for gingival crevicular fluid (GCF) sample collection, biomarker analytical methods, and the variability of biomarker quantification, even when using the same analytical technique. Methodology. An electronic search was conducted on in vivo studies that presented clinical data on techniques used for GCF collection and biomarker analysis. Results. The results showed that 71.1%, 24.7%, and 4.1% of the studies used absorption, microcapillary, and washing techniques, respectively, in their gingival crevicular fluid collection. 73.1% of the researchers analyzed their samples by using enzyme-linked immunosorbent assay (ELISA). 22.6%, 19.5%, and 18.5% of the researchers included interleukin-1 beta (IL-1β), matrix metalloproteinase-8 (MMP-8), and tumor necrosis factor-alpha (TNF-α), respectively, in their studies as biomarkers for periodontal disease. Conclusion. IL-1β can be considered among the most common biomarkers that give precise results and can be used as an indicator of periodontal disease progression. Furthermore, paper strips are the most convenient and accurate method for gingival crevicular fluid collection, while enzyme-linked immunosorbent assay can be considered the most conventional method for the diagnosis of biofluids.
机译:背景。在过去的几十年中,有几项研究致力于寻找一种早期诊断牙周病的精确方法。目标。为了从当前的科学文献中评估牙龈沟液(GCF)样品收集,生物标志物分析方法和生物标志物定量变异性的最常用和最精确的方法,即使使用相同的分析技术也是如此。方法。对体内研究进行了电子搜索,该研究提供了有关用于GCF收集和生物标志物分析的技术的临床数据。结果。结果显示,分别有71.1%,24.7%和4.1%的研究在牙龈沟液收集中使用了吸收,微毛细管和清洗技术。 73.1%的研究人员通过酶联免疫吸附测定(ELISA)分析了样品。在他们的研究中,分别有22.6%,19.5%和18.5%的研究者包括白介素1β(IL-1β),基质金属蛋白酶8(MMP-8)和肿瘤坏死因子α(TNF-α)。作为牙周疾病的生物标志物。结论。 IL-1β可被认为是可以提供精确结果的最常见生物标志物之一,并且可以用作牙周疾病进展的指标。此外,纸条是牙龈龈沟液收集的最方便,最准确的方法,而酶联免疫吸附法可被认为是诊断生物流体的最常规方法。

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