How do multi-stage multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

机译：与传统的两臂并联组设计相比多阶段多臂试验如何进行比较–对4个试验进行了重新分析

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摘要

BackgroundTo speed up the evaluation of new therapies, the multi-arm, multi-stage trial design was suggested previously by the authors.

机译：背景技术为了加快对新疗法的评估，作者先前曾提出多臂，多阶段的试验设计。

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期刊名称 Current Controlled Trials in Cardiovascular Medicine
作者
FM-S Barthel; MKB Parmar; P Royston;
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作者单位

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年(卷),期 2009(10),-1
年度 2009
页码 21
总页数 10
原文格式 PDF
正文语种
中图分类心血管疾病;
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专利

1. How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials [J] . FM-S Barthel, MKB Parmar, P Royston Trials . 2009,第1期

机译：与传统的两臂并联组设计相比，多阶段，多臂试验如何进行比较–对4个试验进行了重新分析
2. The design of a multi-arm multi-stage (MAMS) phase III randomised controlled trial comparing alternative regimens for escalating (COMPARE) treatment of intermediate and high-risk oropharyngeal cancer with reflections on the complications of introducing a new experimental ARM [J] . Piers Gaunt, Hisham Mehanna, Christina Yap Trials . 2015,第SUPPLEMENTa2期

机译：多臂多阶段（MAMS）III期随机对照试验的设计，比较了中度和高风险口咽癌的逐步升级（COMPARE）治疗的替代方案，并考虑了引入新的实验性ARM的并发症
3. Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial [J] . Matthew R Sydes, Mahesh KB Parmar, Malcolm D Mason, Trials . 2012,第1期

机译：实践中灵活的试验设计-在STAMPEDE中停止缺乏治疗的武器并在中期试验中添加研究武器：多臂多阶段随机对照试验
4. Field trial to compare the efficacy of Mycoplasma hyopnevmoniae vaccination compared with lincocin~(TM) premix and the combination of both products [C] . P. Latell, E. Neike Congress of the International Pig Veterinary Society . 1999

机译：实地试验，比较与林科蛋白〜（TM）预混物相比的支原体杂交疫苗接种疫苗接种的疗效以及两种产品的组合
5. Optimal Designs for Two-Arm Randomized Phase II Clinical Trials with Multiple Constraints. [D] . Jiang, Wei. 2014

机译：具有多个约束的两臂随机II期临床试验的优化设计。
6. The design of a multi-arm multi-stage (MAMS) phase III randomised controlled trial comparing alternative regimens for escalating (COMPARE) treatment of intermediate and high-risk oropharyngeal cancer with reflections on the complications of introducing a new experimental ARM [O] . Piers Gaunt, Hisham Mehanna, Christina Yap 2015

机译：多臂多阶段（MAMS）III期随机对照试验的设计比较了逐步升级（COMPARE）治疗中度和高风险口咽癌的替代方案并反思了引入新的实验性ARM的并发症
7. How do multi-stage, multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials [O] . 2009

机译：与传统的两臂并联组设计相比，多阶段，多臂试验如何进行比较–对4个试验进行了重新分析

How do multi-stage multi-arm trials compare to the traditional two-arm parallel group design – a reanalysis of 4 trials

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