Objective: To investigate the association between the S447X polymorphis m of th e lipoprotein lipase (LPL) gene and lipoprotein lipid and blood pressure (BP) le vels in 904 Chinese subjects with essential hypertension. Method: Five hundred a nd sixty-three male and 341 female patients (aged 35-69 years) were randomly s elected from hypertensive patients diagnosed in the Community-based Comprehensi ve Studies on Prevention and Control of Hypertension Project in China (CCPACH) a nd not treated with antihypertensive medications for at least 2 weeks immediatel y before blood collection. Results: After multivariate adjustment for age, body mass index (BMI), smoking status, alcohol intake and serum glucose, the X447 all ele was significantly associated with low triglyceride, log triglyceride: high- density lipoprotein (HDL)-cholesterol ratio and high HDL-cholesterol levels co mpared with the S447S genotype, but not with BP levels in the whole study popula tion. However, upon stratification for dyslipidemic status, the X447 allele was associated with higher systolic blood pressure (SB P) (P< 0.05) and pulse pressure (PP) (P< 0.05) compared with the S447S genotype after multivariate adjustment in dyslipidemic subjects, but not in those without dyslipidemia. A statistically significant interaction between the LPL S447X pol ymorphism and dyslipidemic status was observed for SBP and PP levels, suggesting that dyslipidemic status might modify the effect of the LPL S447X polymorphismo n BP levels. Conclusions: Our findings suggest that a high concentration of trig lyceride and/or low concentration of HDL-cholesterol are associated with high S BP and PP in hypertensive patients with the X447 allele of the LPL gene.
展开▼
