滋肾泻火中药治疗多囊卵巢综合征高睾酮血症30例

摘要

目的：观察滋肾泻火中药治疗肾阴虚火旺型多囊卵巢综合征（Polycystic Ovary Syndrome，PCOS）高睾酮血症的临床疗效。方法：选取30例肾阴虚火旺型 PCOS 高睾酮血症患者，予加减知柏地黄汤口服，1剂／d，连服3个月。观察治疗前后血清睾酮（T）、卵泡刺激素（FSH）、促黄体生成素（LH）、雌二醇（E2）、泌乳素（PRL）、空腹胰岛素（FINS）以及月经周期、症状、痤疮评分、基础体温（BBT）双相率、卵巢体积、血常规、丙氨酸氨基转移酶、肌酐、尿素氮等。结果：治疗后，患者血清T 和月经周期、中医症状及痤疮评分等均较治疗前明显降低（P ＜0.01；P ＜0.05），46.7％的患者基础体温出现双相，FSH、LH、E2、PRL、FINS、卵巢体积、血常规、肝肾功能与疗前相比差异无统计学意义（P ＞0.05）。结论：滋肾泻火中药能有效降低肾阴虚火旺型 PCOS 高睾酮血症，改善高雄激素的临床表现，有一定促进患者恢复自发排卵作用。%Objective:To observe the efficacy of tonifying Kidney-yin and fire-clearing prescription in treating polycystic ovary syn-drome (PCOS)with high testosterone.Methods:Thirty patients with PCOS accompanied high testosterone were recruited and trea-ted with Zhibai Dihuang Formula for 3 months.The efficacy was evaluated after treatment.The serum testosterone (T)and folli-cle-stimulating hormone (FSH),luteinizing hormone (LH),estrogen (E2 ),prolactin (PRL),Fasting insulin (FINS),the scores of menstruation,the scores of TCMsymptoms,the scores of acne,the basal body temperature (BBT),the volume of ovari-an,routine blood test,alanine aminotransferase (ALT),creatinine (CR)and urea nitrogen (BUN)were compared between be-fore and after treatment.Results:3 months later,the serum testosterone level,the scores of menstruation,the scores of TCM symptoms and the scores of acne were lower after treatment than that of before treatment (P <0.01 ;P <0.05 =.46.7% of the patients manifested bipolar order on basal body temperature,but FSH,LH,E2 ,PRL,FINS,the volume of ovarian,routine blood test,ALT,CR and BUN had no obvious change(P >0.05).Conclusion:Tonifying kidney-yin and clearing fire method proved efficient on lowering serum T,improving the clinical manifestations of hyperandrogenism of PCOS,and promoting patients recovery of spontaneous ovulation.