COVID-19 has swept the world for almost three years, while the causing agent SARS-CoV-2 virus has been continuously evolving. In this issue, Virologica Sinica presents a special topic on COVID-19 and includes a collection of original articles on the characteristics of novel variants and their diagnostics and treatment, immune protection and escape of vaccines and therapeutic antibodies, basic virology and viral decontamination strategies, and et al.
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