锌对胎儿生长发育影响的临床研究

摘要

为探讨锌与胎儿生长发育的关系，将66例新生儿按出生体重分为小于胎龄儿组（SGA组，出生体重小于同胎龄正常标准体重的第10百分位）及适于胎龄儿组（AGA组，出生体重在同胎龄正常标准体重的第10～90百分位）。分别测定两组脐血中锌含量及胰岛素样生长因子-1（IGF-1）、胰岛素样生长因子结合蛋白-3（IGFBP-3）水平。结果显示，SGA组脐血锌含量及IGF-1、IGFBP-3水平均显著降低，与AGA组比较有显著差异（P均＜0．01）；锌浓度随出生体重和胎龄的增加而增加（P均＜0．01），与IGF-1、IGFBP-3水平呈正相关（P均＜0．01）。认为胎儿发育与体内锌含量密切相关，缺锌可导致胎儿宫内发育迟缓；胎儿母亲孕期应适量补锌。%To determine the relationship between Zinc concentration and prenatal growth，66 newborns were divided into small for gestational age（SGA）group and appropriate for gestationa age（AGA）group according to their birthweight and gestational ages．The serum Zinc concentration，insulin-like growth factor-1（IGF-1）and insulin-like growth factor binding protein-3（IGFBP-3）levels in cord blood of newborms were measured by atomic absorption spectroscopy，radioimmunoassay（RIA）and immunoradioassays（IRMA）respectively．Results showed that the concentration of Zinc and the levels of IGF-1，IGFBP-3 were significantly lower in SGA group than those in AGA group（P＜0．01，respectively）．This suggests that the fetal growth correlates closely with Zinc concentration．Lacking of Zinc can result in intrauterine growth retardation．Zinc supplement is necessary for mother during pregnancy．