血清脂蛋白（a）与Alzheimer病关系探讨

摘要

为探讨血清脂蛋白（a）［Lp（a）］与Alzheimer病（AD）的关系。对58例AD患者和160例健康人的血清血脂、载脂蛋白和Lp（a）进行检测。结果：AD患者的Lp（a）水平（中位数）及异常率均明显高于对照组（392.38／156.32，P＜0.01；46.72％／20.04％，P＜0.01）。多元逐步回归分析显示，与甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）相比，LP（a）与AD之间有更显著的回归关系（β＝0.28，P＝0.0001，复相关系数为0.49）。提示高水平的LP（a）是AD的重要危险因素，检测血清Lp（a）对诊断AD有重要参考价值。%To study the relationship between concentration of lipoprotein（a）［LP（a）］and ALzheimer’s disease（AD）.The concentration of Lp（a），apoA１，apoB and blood-lipids were anlysed in 58 cases of Alzheimer’s disease and 110 cases of normal group.Results showed that the Lp（a） level and its abnormal rate of patient group were significantly higher than those of the normal group （392.38／156.32，P＜0.01；46.72％／20.04％，P＜0.01）．Multivariate regression analysis revealed that the Lp（a） was a significant variable associated with AD compared with either TG or LDL-C.It suggest that the high level Lp（a） may play an important role in onset of AD and thus Lp（a） is a better predicting index for AD risk.