诱生型一氧化氮合酶在肝癌中表达的意义

摘要

为证实诱生型一氧化氮合酶（iNOS）在肝癌发生、发展中的作用，采用免疫组化方法对50例原发性肝细胞癌（HCC）及癌旁组织（PCHT）中的iNOS表达情况进行了检测。结果显示，iNOS位于肝细胞细胞浆／膜中，在HCC中的表达强度变化较大，在PCHT中呈强表达；正常肝组织中呈弱表达；淋巴细胞中无表达。证实iNOS的异常表达可导致HCC患者体内NO生成异常及机体对癌细胞的免疫异常。提示提高体内NO合成，可望提高HCC患者的抗癌能力。%To study the production and significance of nitric oxide（NO）inhuman hepatocelluar carcinoma.（HCC） Immunochemihistorical method was used for determining iNOS of 50 patients with HCC iNOS appeared in the plasma or membrane of the hepatic cells and kupffer’s cells.There was no iNOS in lymphocytes.The degrees of iNOS expression between HCC and paracancerous hepatic tissues （PCHT） had statistical difference，so did between Edmondson’s grade of Ⅱ，Ⅲ，Ⅳ.NO was related to the differentiation of HCC.The abnormality of expression of iNOS have effects on the immune reactivity of body to the cancer cells in some degree.Improving the NO production in the HCC cells may increase the antitumor ability of the patients.