Objective To study the risk factors for type 2 diabetics with foot gangrene. Methods Diabetic foot patients were retrospectively investigated regarding their demographic date, previous history of chronic diseases, with chronic complications, and blood biochemistry parameters. Multivariate unconditional logistic regression was used to analyze the clinical data. Results Higher prevalence of diabetic peripheral neuropathy ( DPN) and arteriosdereis obliterans ( ASO) , lower ankle brachial index (ABI), higher white blood cell count, higher sensitivity C-reactive protein level, and lower plasma albumin were found in gangrene group compared with the non-gangrene group. Multivariate unconditional logistic regression showed that lower ABI, lower plasma albumin, higher white blood cell count were the independent risk factors of gangrene. Conclusion Infection, lower limb vascular occlusion, poor nutritional status are important factors leading to gangrene due to the unhealed ulcers.%目的 探讨2型糖尿病患者糖尿病足坏疽的危险因素.方法 回顾性分析糖尿病足患者的一般资料、既往病史、合并慢性并发症及实验室检查指标,并进行多因素非条件Logistic回归分析.结果 与非坏疽组相比坏疽组患者合并糖尿病神经病变发生率、下肢血管病变发生率更高,踝肱指数明显降低,白细胞计数、超敏C反应蛋白明显升高,血浆白蛋白明显降低.多因素非条件Logistic回归分析显示踝肱指数减小、血浆白蛋白减少、高白细胞计数是糖尿病足坏疽的独立危险因素.结论 感染、下肢血管中重度闭塞、营养状况低下是糖尿病足溃疡发展为坏疽的危险因素.
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