糖代谢异常和代谢综合征组分数量对颈动脉内膜中膜厚度的影响

摘要

目的 探讨糖代谢异常和代谢综合征组分数量对颈动脉内膜中膜厚度(IMT)的影响.方法 183例受试者分为正常糖耐量组、糖耐量受损组和糖尿病组,在上述分组的基础上,根据2005年国际糖尿病联盟代谢综合征的定义,各组再分为组A(代谢综合征组分数量0～2个)和组B(代谢综合征组分数量3～5个)2个亚组,超声检测颈动脉IMT.结果 糖尿病组、糖耐量受损组和正常糖耐量组颈动脉IMT分别为(0.66±0.14)、(0.64±0.12)和(0.60±0.11) mm,其中糖尿病组与正常糖耐量组比较,差异有统计学意义(P＜0.05)；正常糖耐量组中,组A和组B IMT比较,差异有统计学意义(P＜0.05)；糖尿病组和糖耐量受损组中,组A和组B IMT比较,差异无统计学意义(P＞0.05).结论 糖尿病患者颈动脉IMT值显著高于正常糖耐量者,代谢综合征组分数量对颈动脉IMT的影响在正常糖耐量者比对糖尿病和糖耐量受损者更明显.%Objective To investigate the impact of the metabolic syndrome (MS) on intima-media thickness (IMT) of carotid arteries in the subjects with varying degrees of abnormity of glucose metabolism. Methods A total of 183 participants were firstly divided into the group of normal glucose tolerance ( NGT) , the group of impaired glucose tolerance (IGT) and the group of type 2 diabetes mellitus (DM). Each group was divided into the subgroups with or without MS. The carotid IMT was detected with color ultrasonography. Results The IMT of the carotid arteries in NGT, IGT and DM group were (0.60 ±0.11), (0.64 ±0.12) and (0.66 ±0. 14) mm, respectively. The carotid IMT in NGT group was significantly lower than that in DM group (P<0.05); The carotid IMT in the subgroup without MS was significantly lower than that of the subgroup with MS in NGT group (P < 0.05). There were no significant differences in the carotid IMT among the other subgroups (P>0.05). Conclusions There was a different impact of MS on the IMT in the carotid arteries in the subjects with varying degrees of abnormity of glucose metabolism. It was relative prominence in the subjects with NGT.