血清胱抑素C及尿微量白蛋白对妊娠期糖尿病患者肾功能评价的临床意义

摘要

目的 探讨血清胱抑素C(Cys C)、尿微量白蛋白(mALB)对妊娠糖尿病(GDM)患者肾损害的早期诊断价值.方法 用免疫比浊法检测血清Cys C、mALB水平,用酶法检测血尿素氮(BUN)、肌酐(Scr)水平.结果 GDM组与对照组Cys C、尿mALB、Scr比较差异均有统计学意义(P＜0.05或＜0.01)；GDM组BUN水平高于对照组,但差异无统计学意义(P＞0.05).结论 联合检测Cys C、mALB对更好的早期诊断GDM肾病具有重要意义.%Objective To study the early diagnosis value of serum cystatin C and urine microalbumin on renal injures of gestational diabetes meilitus patients. Methods The concentration of cystatin C and urine microalbuminuria were determined by nephelometry method. The levels of the blood urea nitrogen ( BUN) and the creatinine (Scr) were measured by enzymatic method. Results The levels of cystatin C, urine microalbuminuria and Scr in patients with gestational diabetes meilitus were obviously higher than those of the normal group (P <0.05 or <0.01). The level of BUN had no significant difference in the two group ( P > 0.05 ). Conclusion The cystatin C and urine microalbuminuria quantified together have important significance in the early diagnosis in patients with gestational diabetes meilitus.