BV和VVC患者阴道灌洗液中相关细胞因子水平检测及意义

摘要

目的 提高细菌性阴道病(BV)和外阴阴道假丝酵母菌病(VVC)诊疗水平.方法 采集35例健康育龄妇女(对照组)、35例BV患者(BV组)、35例VVC患者(VVC组)阴道灌洗液,用ELISA法检测三组相关细胞因子(IL-2、IL-8、IFN-γ、IL-4、IL-13、IL-10、IgE)水平.结果 与对照组比较,BV组IL-2显著降低,IL-13、IL-4、IL-10显著升高,IL-8、IFN-γ、IgE无明显变化;VVC组IFN-γ显著降低,IL-2、IL-13、IL-4、IgE显著升高,IL-8、IL-10无显著变化.讨论 BV与VVC均存在Th1/Th2平衡失调,检测两种疾病局部细胞因子的变化有助于更好的控制感染.%Objective To improve the diagnosis and treament level of bacterial vaginosis(BV) and vulvovaginal candidiasis(VVC).Methods Cervicovaginal lavage fluid was collected from 35 healthy women in child-bearing age ( control group) ,35 patients with BC(BV group) ,35 patients with VVC (WC group).The level of cytokines (IL-2, IL-8,IFN-γ,IL-4,IL-13 ,IL-10,IgE)of the three groups were detected by ELISA.Results Compared with the control group, the IL-2 of BV group decreased significantly,IL-13,IL-4,IL-10 increased significantly,IL-8,IFN-γ,IgE had no significant change;the IFN-γof VVC group decreased significantly, IL-2,IL-13,IL-4,IgE increased obviously,IL-8,IL-10 had no significant change.Conclusions The un-balance of Th1/Th2 is common in BV and VVC, detecting the changes of local cytokine is helpful for controling their inflammation better.