宫颈未成熟鳞状上皮化生和高级别鳞状上皮内病变中细胞角蛋白及Ki-67的表达

摘要

Objective To investigate the value of cytokeratin and Ki-67 in cervical immature squamous metaplasia (ISM) and high-grade squamous intaepthelial lesion( HGSIL). Methods The expression of Ki-67 and CK7, CK10/13,CK17 were detected immunohistochemically in ISM and HGSIL,and the cervical normal squamous epithelium (NSE) was chosen as control. Results The expression of CK7,CK17 and Ki-67 in HGSIL were significantly higher than those in ISM ( all P =0. 000 ), the expression of CK10/13 in HGSIL was significantly lower than that in ISM( P =0. 000). Conclusion Co-detection of CK7 ,CK10/13,CK17 and Ki-67 is helpful for the differential diagnosis of ISM and HGSIL.%目的 探讨细胞角蛋白(CK)和增殖细胞核抗原Ki-67在鉴别宫颈未成熟鳞状上皮化生(ISM)与高级别鳞状上皮内病变(HGSIL)中的意义.方法 应用免疫组化Power Vision二步法检测Ki-67和CK7、CK10/13、CK17在ISM和HGSIL中的表达情况,并以正常宫颈鳞状上皮(NSE)做对照.结果 CK7、CK17、Ki67在HGSIL的阳性表达率均明显高于ISM(P 均=0.000),CK10/13在HGSIL的阳性表达率均明显低于XSM(P=0.000).结论 CK7、CK10/13、CK17和Ki-67的联合检测有助于ISM和HGSIL的鉴别诊断.