Peutz-Jeghers综合征中Brg1蛋白的表达及临床意义

摘要

目的 探讨Peutz-Jeghers综合征(PJS)中Brg1蛋白的表达及其在PJS息肉发展过程中的作用.方法 应用免疫组化法检测Brg1蛋白在72例PJS息肉组织、12例正常小肠黏膜组织、30例小肠癌组织中的表达,并探讨其与PJS息肉发生、发展及癌变的关系.结果 Brg1蛋白在小肠癌组中的阳性表达率为76.67%,PJS息肉组织为54.17%,正常小肠黏膜组织为16.67%;PJS息肉组和正常小肠黏膜组Brg1蛋白阳性表达差异有统计学意义(P＜0.05);PJS息肉组和小肠癌组Brg1蛋白阳性表达差异有统计学意义(P＜0.05).结论 Brg1蛋白在小肠癌组织中存在过高表达,在PJS息肉组织中存在高表达,且可能是PJS息肉癌变的关键因子之一.%Objective To investigate the expression of Brgl protein in Peutz-Jeghers syndrome, and to study its relation with polyps development.Methods The expressions of Brgl protein were detected by immunohistochemical streptavidin-perosidase in 72 cases of Peutz-Jeghers, 30 cases of cancer and 12 cases of normal tissue.The role of Brg1 protein in ofPeutz-Jeghers development and prognosis was analyzed.Results In 30 cases of cancer, 76.67％ of Brg1 protein expression were detected, which was higher than that in PJS tissue 54.17％ and in normal tissue 16.67％.There were significant differences among three groups (P ＜ 0.05 ).Conclusion An increased expression of Brgl protein in PJS associates with the development.