目的 探讨Fisher综合征(MFS)的临床特点和发病机制,加深对本病的认识.方法 回顾性分析9例MFS(其中复发型MFS 1例)患者的临床资料,分析其临床特点.结果 9例均有共济失调、眼肌麻痹、腱反射减弱或消失的三联征表现；病理反射均为阴性；6例患者存在四肢乏力.辅助检查:4例发病2-4周脑脊液出现蛋白一细胞分离现象；8例行肌电图检查均提示神经源性损害；头颅MRI或CT检查均正常.丙种球蛋白治疗后病情均有所缓解.结论 MFS为自限性疾病,预后较好；复发型病例罕见；丙种球蛋白治疗MFS有效.%Objective To investigate the clinical features and pathogenesis of Miller Fisher syndrome ( MFS), and deepen understanding of the disease . Methods The clinical data of nine MFS cases were analyzed retrospectively.rnResults The neurological symptoms and signs of all patients were diplopia , ophthalmoplegia and tendon areflexia ( 9 cases) , negative pathological reflexes(9 cases) ,and limb weakness(6 cases). Supplementary examination; increased protein (4 patients) was detected in the cerebrospinal fluid, but the number of cells was normal in 2-4 weeks;eight patients were found neural injury in electromyography (EMG) ;no positive finding in computer tomography (CT) or magnetic resonance imaging (MRI) were found. Patients had a good response to intravenous immunoglobulins. Conclusions MFS is a self-limiting disease, and the prognosis was good; the recurrent pattern can be considered a rare type; intravenous immunoglobulins treatment is effective.
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