射频毁损灶体积与近红外光学参数的相关性分析

摘要

目的 观察射频毁损灶体积与近红外光学参数(优化散射系数,μ's)的相关性,并建立毁损灶体积与μ's的回归方程.方法 利用正常大鼠建立不同毁损时间、温度下的毁损灶体积模型,通过病理检测及MRI确定毁损灶最大直径、高,经公式转换成体积,毁损过程中记录μ's的变化.结果 不同毁损条件下,随着毁损灶体积的规律性变化,μ's出现规律性变化.结论 μ's可以实时反映毁损灶体积的变化,可作为射频毁损手术的实时监控指标,对临床有一定的指导意义.%Objective To observe the correlation between the volume of radiofrequency and near-infrared optical properties (reduced scattering coefficient, μ' s) by near infrared spectroscopy, MRI and pathological examination. Methods The volume model of radiofrequency under different time or temperature in the adult rats was established. The height and maximum lesion diameter were detected by pathology testing and MRI, then converted the dates to volume with the formula, during the radiofrequency ablation the changes of μ' s were recorded. Results Under different damage conditions, the μ' s changed regularly with the volume of radiofrequency changing regularly. Conclusions μ' s reflects the changes of the volume of radiofrequency immediately, the μ' s can be used as an real-time monitoring during the radiofrequency ablation surgery, and it plays an indicator roles in the clinic.