冠心病患者外周血NT-proBNP水平与GRACE评分的相关性分析

摘要

目的 探讨不同危险分层的冠心病患者氮末端脑钠素原(NT-proBNP)的水平变化及其与全球急性冠状动脉事件注册(GRACE)评分的相关性.方法 选择168例经过冠脉造影检查的冠心病患者,根据冠脉狭窄情况将其分为3组:正常对照组41例,稳定型心绞痛(SAP)组(SAP组)69例,急性冠脉综合征(ACS)组(ACS组)58例.用放射免疫法测定各组外周血NT-proBNP水平,并进行GRACE危险评分及分层.结果 ACS组外周血NT-proBNP水平均高于SAP组及正常对照组(P均＜0.05).ACS组GRACE评分均高于正常对照组及SAP组(P均＜0.05).NT-proBNP水平与GRACE评分呈正相关关系(r=0.318,P＜0.01).GRACE评分高危者血NF-proBNP水平高于中、低危者(P均＜0.01).结论 ACS患者外周血NT-proBNP水平升高,并与GRACE评分有关,NT-proBNP水平越高,ACS风险越高.%Objective To investigate the serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients with coronary heart disease (CHD) and its correlation with global registry of acute coronary events (GRACE) score,and then to assess the risk of CHD with the combination of them.Methods A total of 168 cases of patients who underwent coronary angiography were selected as research subjects.They were divided into three groups by coronary angiography:41 cases of patients with non-coronary heart disease as control group; 69 cases of patients with stable angina pectoris as SAP group; 58 cases of patients with acute coronary syndrome as ACS group.The NT-proBNP levels of all patients were measured by radioimmunoassay.All patients were scored by GRACE system,and then layered.Results The NT-proBNP levels and GRACE score in ACS group were significantly higher than the control group and the SAP group (all P ＜ 0.05).Then the NT-proBNP levels and GRACE score had significant positive correlation (r =0.318,P ＜ 0.01).The NT-proBNP levels in high risk GRACE score patients were higher than the moderated and low risk GRACE score ones (all P ＜ 0.01).Conclusion The NT-proBNP levels in patients with acute coronary syndrome are positively correlated with GRACE risk score,and the higher the NT-proBNP levels are,the higher the risk of ACS becomes.