病毒性心肌炎患者血清 IL17、IL35水平变化及意义

摘要

Objective To investigate the expression and its clinical significance of serum interleukin -17 ( IL-17 ) and interleukin-35(IL-35) in patients with viral moycarditis (VMC).Methods Seventy patients with VMC(VMC group, 41 in acute stage and 29 in remission stage ) and 30 healthy subjects ( control group ) were enrolled , Enzyme-linked immu-nosorbent assay(ELISA) was used to detect the blood serum level of IL-17 and IL-35, and chemiluminescent microparticle immunoassa was used to detect the blood serum level of cardiac troponin I (cTnI).The relationship among the indexes were analyzed.Results The serum level of IL-17 and cTnI in VMC group were both higher than those in the control group ,and the IL-35 was in the contrary, especially for the patients in acute stage ( all P<0.05).The serum level of IL-17 and IL-35 showed positive and negative corelation to the cTnI , r=0.681,-0.583( both P<0.05);IL-17 was negatively correlated to IL-35,r=-0.482,P<0.01.Conclusion The blood serum level of IL-17 and IL-35 in VMC patients is abnormal and correlated to the codition , these two indexes may be involved in the pathogenesis and development of VMC .%目的：观察病毒性心肌炎（ VMC）患者血清IL-17、IL-35水平变化，探讨其意义。方法选择70例VMC患者（ VMC组，其中急性期41例、恢复期29例）及30例健康查体者（对照组），采用ELISA法检测血清IL-17、IL-35水平，采用微粒子化学发光免疫分析法检测心肌肌钙蛋白I（ cTnI）水平，分析各指标相关性。结果 VMC组血清IL-17及cTnI水平均显著高于对照组、血清IL-35水平显著低于对照组，尤以急性期为著（P均＜0．05）。 VMC组血清IL-17和IL-35分别与cTnI水平呈正相关、负相关，r值分别为0．681、-0．583，P均＜0．05；血清IL-17与IL-35水平呈负相关，r＝-0．482，P＜0．01。结论 VMC患者血清IL-17与IL-35水平异常并与病情有关，两者可能共同参与了VMC的发生、发展。