东亚人群 TNF-α基因启动子238 G／A 多态性与乙型肝炎易感性关系的 Meta 分析

摘要

目的：探讨东亚人群肿瘤坏死因子α（ TNF-α）基因启动子238G/A多态性与乙型肝炎易感性是否存在相关性。方法检索EMBASE、Ovid、PubMed、Highwire press、CBM、CNKI、万方等数据库中国内外公开发表的TNF-α基因启动子238G/A多态性与乙型肝炎易感性的研究，进行筛选后对符合标准的文献进行数据提取和Meta分析。结果最终纳入符合要求的文献7篇，病例组2472例，对照组1454例。病例组中野生纯合子（ GG）、突变纯合子（AA）和野生杂合子（GA）的基因型频率分别为90．8％、0．5％、8．7％，对照组分别为93．1％、0．3％、6．6％；两组各基因型频率比较，P均＞0．05。携带AA者感染HBV的风险与携带GG者比较无显著差异；显性模式下携带AA＋GA者感染HBV的风险与携带GG者比较，隐性模式下携带AA者感染HBV的风险与携带GG＋GA者比较，P均＞0．05。结论东亚人群TNF-α基因启动子238G/A多态性与乙型肝炎易感性不存在关联。%Objective To evaluate the relationship between TNF-αgenetic promoter 238G/A polymorphism and sus-ceptibility to hepatitis B by meta-analysis.Methods By searching EMBASE, PubMed, Ovid, Highwire press, CNKI, CBM and WANFANG et al, we collected studies about TNF-αgenetic promoter 238G/A polymorphism and HBV infection susceptibility.The odds ratios (OR) of variant allele of TNF-αgenetic promoter 238G/A and publication bias were calcu-lated by using Stata11.0 software.After screening and quality evaluation , data extraction was conducted in the literature which met the standard and then the literature was given meta-analysis .Results A total of 2 472 cases and 1 454 controls were included in 7 studies.The genotype frequencies of GG , AA and GA in the case group were 90.8%, 0.5% and 8.7%, while 93.1%, 0.3%, and 6.6%in the control group, all P>0.05.There was no significant difference between the AA and GG group;for the dominant genetic model , there was no significant difference between the AA +GA and GG group, for the recessive genetic model , there was no significant difference between the AA and GG +GA group, all P>0.05.Conclusion There was no close relationship between TNF-αgenetic promoter 238G/A polymorphism and HBV in-fection susceptibility .