化湿行瘀清热方剂治疗的口腔扁平苔藓患者效果及其唾液白蛋白、分泌型 IgA 水平观察

摘要

Objective To evaluate the clinical efficacy of Huashi Xingyu Qingre decoction (HXQD) in treatment of oral lichen planus ( OLP) , and to analyze the effects of HXQD on the content of OLP patients'ALB and secretory IgA ( sI-gA) in saliva.Methods Thirty cases of OLP patients ( observation group) were treated by HXQD, 200 mL, once respec-tively each morning and evening, agent 1/d, and for 8 weeks.Meanwhile, 30 healthy people were selected as the control group.The saliva samples of OLP patients and healthy people were collected to detect serum albumin and sIgA in saliva be-fore and after treatment.Results After treatment, 16 cases were significantly effective, 11 cases were effective, 3 cases were invalid in the observation group, and the total effective rate was 90%(27/30).OLP The level of ALB in saliva was higher and sIgA was lower in observation group than that of the control group before treatment (all P<0.05).Compared with before treatment, the content of ALB was decreased after treatment, while the level of sIgA was increased, and the differences were statistically significant (all P<0.05).Conclusions HXQD has significant clinical effect on OLP, and it can reduce ALB and increase sIgA in OLP patients'saliva.%目的：观察化湿行瘀清热方剂治疗的口腔扁平苔藓（OLP）患者的临床疗效，并分析其唾液白蛋白、分泌型IgA水平。方法30例OLP患者（观察组）采用化湿行瘀清热方剂水煎取汁200mL，早晚各1次，1剂／d，共治疗8周，观察疗效。同时选择30例健康者为对照组。分别采集观察组治疗前后和对照组的唾液标本，检测唾液白蛋白（ALB）、分泌型IgA（sIgA）。结果治疗后观察组显效16例、有效11例、无效3例，治疗总有效率90％（27／30）。治疗前观察组唾液ALB水平高于对照组，sIgA水平低于对照组，P均＜0．05；与治疗前比较，治疗后观察组唾液ALB水平降低，sIgA水平升高，P均＜0．05。结论化湿行瘀清热方剂治疗OLP疗效较好，可降低患者唾液白蛋白、提高sIgA水平。