静电纺丝聚乳酸-羟基乙酸纳米纤维膜与磷酸钙骨水泥复合物力学性能的研究

摘要

Objective A compound of Poly(lactide-co-glycolide acid)(PLGA)and calcium phosphate cement(CPC)was pre-pared that imitated the concentric structures of natural bone .Then,the effect of electrospun PLGA nanofiber membrane on toughness strength of CPC was explored by using a mechanical experiment .Methods The PLGA/CPC compound or pure CPC were prepared to be cuboid specimens with size of 6 mm×6 mm×20 mm.The toughness strength ,bending strength and modulus of elasticity of the materi-als were tested by the three-point flexural test .Results The toughness strength of the PLGA/CPC compound was 71.4 times higher than that of the pure CPC ( P =0.00 ) .However ,there were no significant difference in the bending strength and modulus of elasticity although the former was increased by 28.8%while the latter was reduced by 37.8%.Conclusion Electrospun PLGA nanofiber mem-brane can improve the toughness of CPC ,and the compound shows a good mechanical property .%目的：模仿天然骨同心圆的结构，制备静电纺丝聚乳酸-羟基乙酸共聚物[ Poly （ lactide-co-glycolide acid ）， PL-GA]纳米纤维膜/磷酸钙骨水泥（ calcium phosphate cement ，CPC）复合物，通过力学实验初步探讨静电纺丝PLGA纳米纤维膜改善CPC韧性强度的效果。方法实验分为两组：实验组为CPC/PLGA复合物、对照组为单纯的CPC，将CPC复合物或单纯的CPC制备6 mm×6 mm×20 mm的长方体试件，进行三点弯曲试验测试材料的韧性强度、弯曲强度和弹性模量。结果与CPC组相比较，CPC/PLGA组的韧性强度提高了71.4倍，差异具有统计学意义（ P ＝0.00）；弯曲强度提高28.8％，弹性模量降低37.8％，差异无统计学意义（ P＞0.05）。结论静电纺丝PLGA纳米纤维膜可以改善CPC的韧性，静电纺丝PLGA纳米纤维膜/CPC复合物具有较好的力学特性。