缬沙坦联合硝苯地平治疗糖尿病合并高血压的临床疗效观察

摘要

Objective To investigate the effect of valsartan combined with nifedipine on diabetes combined with hyper-tension. Methods From December 2010 to December 2013,96 diabetes patients combined with hypertension in our hospital were chosen,and then they were randomly divided into control group and observation group,48 cases in each. Control group given nifedipine only,observation group given valsartan combined with nifedipine,both groups treated for 12 weeks. SBP, DBP,Scr,BUN and UAER before and after treatment between two groups were compared,and curative effect observed. Re-sults The total effective rate of observation group was 95. 8% ,was higher than that of control group of 72. 9% (P < 0. 05). There was no significant differences of SBP,DBP,Scr,BUN and UAER before treatment between two groups( P > 0. 05), while SBP,DBP,Scr and UAER of observation group were lower than those of control group after treatment(P < 0. 05). Con-clusion Valsartan combined with nifedipine can effectively control the blood pressure and significantly reduce the kidney damage in diabetes patients combined with hypertension.%目的：探讨缬沙坦联合硝苯地平治疗糖尿病合并高血压的临床疗效。方法选取2010年12月-2013年12月我院收治的糖尿病合并高血压患者96例，将其随机分为对照组和观察组，各48例。对照组患者单纯给予硝苯地平进行治疗，观察组患者给予缬沙坦联合硝苯地平进行治疗，两组患者均治疗12周。记录两组患者治疗前后收缩压、舒张压、血肌酐（Scr）、尿素氮（BUN）及尿微量清蛋白排泄率（UAER）变化，并观察两组临床疗效。结果观察组总有效率为95.8%，高于对照组的72.9%（P <0.05）。治疗前两组患者收缩压、舒张压、Scr 、BUN 及 UAER比较，差异均无统计学意义（P >0.05）；治疗后观察组患者收缩压、舒张压、Scr 及 UAER 均低于对照组（P <0.05）。结论缬沙坦联合硝苯地平不但能更好地控制糖尿病合并高血压患者血压，还能有效地改善其肾功能。