目的：观察不同剂量阿托伐他汀治疗冠心病伴高脂血症的临床疗效。方法选择2010年4月-2011年4月我院收治的冠心病伴高脂血症患者50例，将其随机分为对照组和观察组，各25例。对照组患者给予阿托伐他汀15 mg/ d 进行治疗，观察组患者给予阿托伐他汀30 mg/ d 进行治疗，疗程均为2个月。测定治疗前后两组患者 TC、LDL - C 及 HDL - C 水平变化，观察治疗期间不良反应情况。结果治疗前两组患者 TC、HDL - C 及 LDL - C 水平比较，差异均无统计学意义（P ﹥0.05）；治疗后观察组患者 TC 和 LDL - C 水平低于对照组（P ﹤0.05）。治疗期间观察组不良反应发生率为28%，低于对照组的52%（P ﹤0.05）。结论阿托伐他汀30 mg/ d 对冠心病伴高脂血症患者降脂效果优于阿托伐他汀15 mg/ d，且不良反应少。%Objective To observe the clinical effect of different doses of Atorvastatin on coronary heart disease and hy-perlipidemia. Methods From April 2010 to April 2011,50 patients with coronary heart disease and hyperlipidemia in our hos-pital were chosen,and they were randomly divided into control group and observation group,each of 25 cases. Control group giv-en Atorvastatin(15 mg/ d),observation group given Atorvastatin(30 mg/ d),both groups treated for two months. The levels of TC,LDL - C and HDL - C of the two groups were detected before and after treatment,the adverse reactions during treatment were observed. Results There was no significant differences of TC,HDL - C and LDL - C levels between the two groups before treatment(P ﹥ 0. 05);after treatment,the levels of TC and LDL - C of observation group were lower than those of control group (P ﹤ 0. 05). The incidence of adverse reactions of observation group was 28% ,was lower than that of control group of 52% (P﹤ 0. 05). Conclusion Atorvastatin(30 mg/ d)has a better lipid - lowering effect and fewer adverse reactions than Atorvasta-tin(15 mg/ d)on coronary heart disease and hyperlipidemia.
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