奥拉西坦治疗血管性痴呆的临床疗效研究

摘要

Objective To investigate the clinical effect of oxiracetam on vascular dementia( VD). Methods In 2013,75 patients with VD admitted to Department of Cadres Health Care,Qingdao Municipal Hospital,were selected and ran-domly divided into the treatment group(n = 38)and control group(n = 37). Control group given piracetam,treatment group given oxiracetam,both groups treated for 21 days. The scores of MMSE and HDS of the two groups before and after treatment were counted;the clinical effect after treatment and adverse reactions during treatment were observed. Results There was no signifi-cant differences of scores of MMSE and HDS between the two groups before treatment and 14 days after treatment(P ﹥ 0. 05);21 days after treatment,MMSE score and HDS score of control group was(18. 13 ± 2. 66),(18. 31 ± 3. 75),respectively, was lower than that of treatment group of(19. 65 ± 3. 45),(20. 94 ± 3. 79),respectively(P ﹤ 0. 05). The effective rate of treatment group was 86. 8% ,was higher than that of control group of 67. 6% (P ﹤ 0. 05);the incidence of adverse reactions of treatment group was 5. 3% ,that of control group was 13. 5% ,the difference was not statistically significant(P ﹥ 0. 05). Con-clusion Oxiracetam has a certain effect on VD,which can effectively improve patients'mentality,control and mitigate the de-gree of dementia,and is with fewer adverse reactions.%目的：观察奥拉西坦（欧兰同）治疗血管性痴呆（VD）的临床疗效。方法选择2013年青岛市市立医院干部保健科收治的 VD 住院患者75例，将其随机分为治疗组38例和对照组37例。对照组患者给予吡拉西坦治疗，治疗组患者给予奥拉西坦治疗，两组均以21 d 为1个疗程。统计两组患者治疗前、治疗14 d 及21 d 后简易精神状态评价量表（MMSE）[4]和长谷川痴呆量表（HDS）评分；评定治疗后两组临床疗效及观察治疗期间不良反应情况。结果治疗前和治疗14 d 后两组患者 MMSE 评分和 HDS 评分比较，差异均无统计学意义（ P ﹥0.05）；治疗21 d 后对照组MMSE 评分为（18.13±2.66）分、HDS 评分为（18.31±3.75）分，均低于治疗组的（19.65±3.45）分、（20.94±3.79）分（P ﹤0.05）。治疗组有效率为86.8%，高于对照组的67.6%（P ﹤0.05）；不良反应发生率为5.3%，与对照组的13.5%比较，差异无统计学意义（P ﹥0.05）。结论奥拉西坦治疗 VD 疗效显著，能有效提高患者智力，控制和减轻痴呆程度，且未增加不良反应的发生。