Objective To analyze the pathogenic bacteria characteristics and drug resistance of pulmonary tuberculosis patients complicated with lung infection. Methods A total of 314 pulmonary tuberculosis patients complicated with lung infection were selected in the Central Hospital of Xiaogan from March 2011 to April 2015,deep sputum and bronchial lavage fluid were collected to detect the pathogenic bacteria,and its characteristics and drug resistance were analyzed. Results A total of 414 pathogenic bacteria were separated out,including 108 Gram-positive bacteria( accounting for 26. 09% ),290 Gram -negative bacteria(accounting for 70. 05% ),16 fungus(accounting for 3. 86% ). Staphylococcus aureus was the main Gram-positive bacteria(accounting for 13. 53% ),Pseudomonas aeruginosa was the main Gram - negative bacteria( accounting for 22. 22% ),all of the 16 fungus were Monilia albicans. Drug sensitive test result showed that,the drug resistant rate to penicillin of Staphylococcus aureus and Staphylococcus haemolyticus were both 100. 0% ,to vancomycin were both 0;the drug resistant rate to ampicillin of Pseudomonas aeruginosa,Klebsiella pneumoniae,Acinetobacter baumannii,Enterobacter cloacae and Escherichia coli were all 100. 0% ,to imipenem or meropenem of Klebsiella pneumoniae,Enterobacter cloacae and Escherichia coli were all 0,to imipenem or meropenem of Pseudomonas aeruginosa were both 15. 2% ;the drug resistant rate to amikacin of Acinetobacter baumannii was 18. 7% ,to cefoperazone of Acinetobacter baumannii was 21. 9% . Conclusion Gram - negative bacteria is the main pathogenic bacteria of pulmonary tuberculosis patients complicated with lung infection,and Staphylococcus aureus is the main Gram - positive bacteria,Pseudomonas aeruginosa is the main Gram - negative bacteria;the drug resistant rate to vancomycin of Staphylococcus aureus and Staphylococcus haemolyticus are both 0,to imipenem or meropenem of Klebsiella pneumoniae,Enterobacter cloacae and Escherichia coli are 0,and the drug resistant rate to cefoperazone of Acinetobacter baumannii is low.%目的：分析肺结核合并肺部感染患者的菌群分布特点及其耐药性，为临床合理使用抗菌药物提供参考。方法选择2011年3月—2015年4月孝感市中心医院收治的肺结核合并肺部感染患者314例，取患者早晨洗漱后咳出的深部痰或支气管灌洗液进行细菌培养，分析其菌群分布特点及耐药性。结果314份标本共培养出病原菌414株，其中革兰阳性菌108株（占26.09%）、革兰阴性菌290株（占70.05%）、真菌16株（占3.86%）；革兰阳性菌以金黄色葡萄球菌为主（占13.53%），革兰阴性菌以铜绿假单胞菌为主（占22.22%），真菌均为白色假丝酵母菌。药敏试验结果显示，金黄色葡萄球菌和溶血葡萄球菌对青霉素 G 的耐药率为100.0%，对万古霉素的耐药率均为0；铜绿假单胞菌、肺炎克雷伯菌、鲍曼不动杆菌、阴沟肠杆菌、大肠埃希菌对氨苄西林耐药率均为100.0%，肺炎克雷伯菌、阴沟肠杆菌和大肠埃希菌对亚胺培南和美罗培南的耐药率为0，铜绿假单胞菌对亚胺培南和美罗培南的耐药率较低，均为15.2%，鲍曼不动杆菌对阿米卡星和头孢哌酮的耐药率较低，分别为18.7%和21.9%。结论肺结核合并肺部感染患者病原菌以革兰阴性菌为主，主要革兰阳性菌为金黄色葡萄球菌，主要革兰阴性菌为铜绿假单胞菌。金黄色葡萄球菌和溶血葡萄球菌对万古霉素无耐药，肺炎克雷伯菌、阴沟肠杆菌和大肠埃希菌对亚胺培南和美罗培南无耐药，鲍曼不动杆菌对头孢哌酮耐药率低。
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