奥扎格雷钠联合阿司匹林治疗急性脑梗死的临床疗效及对血小板活性的影响研究

摘要

目的：探讨奥扎格雷钠联合阿司匹林治疗急性脑梗死的临床疗效及对血小板活性的影响。方法选择2014年2月—2015年3月上海市中医医院收治的急性脑梗死患者84例，根据治疗方法不同分为对照组（阿司匹林治疗）42例和观察组（奥扎格雷钠联合阿司匹林治疗）42例。比较两组患者的临床疗效及治疗前后血小板计数（PLT）、凝血指标〔包括纤维蛋白原（FIB）、凝血酶原时间（PT）、凝血酶时间（TT）和活化部分凝血活酶时间（ APTT）〕、血栓素 B2（TXB2）及6-酮-前列腺素 F1α（6- K - PGF1α）等；严密监测两组患者治疗期间不良反应情况。结果观察组患者临床疗效优于对照组（P ＜0.05）。治疗前两组患者 PLT、FIB、PT、TT 及 APTT 比较，差异无统计学意义（P ＞0.05）；观察组患者治疗后 PLT 和 FIB 高于对照组，PT 短于对照组，TT 和 APTT 长于对照组（P ＜0.05）。治疗前两组患者 TXB2、6- K - PGF1α比较，差异无统计学意义（P ＞0.05）；治疗后观察组患者 TXB2水平低于对照组、6-K - PGF1α水平高于对照组（P ＜0.05）。治疗期间对照组仅1例患者出现轻度胃肠道不适，自行缓解，且未见其他明显不良反应。结论奥扎格雷钠联合阿司匹林治疗急性脑梗死安全有效，能有效改善患者神经功能缺损症状、提高临床疗效、抑制血小板聚集。%Objective To explore the clinical effect of sodium ozagrel combined with aspirin on acute cerebral infarction and its impact on platelet activity. Methods A total of 84 patients with acute cerebral infarction were selected in Shanghai Traditional Chinese Medicine Hospital from February 2014 to March 2015,and they were divided into control group and observation group according to therapeutic methods,each of 42 cases. Patients of control group were given aspirin only,while patients of observation group were given sodium ozagrel combined with aspirin. Clinical effect,PLT,FIB,PT,TT,APTT, TXB2 and 6 - K - PGF1α before and after treatment were compared between the two groups;incidence of adverse reactions during treatment was recorded. Results The clinical effect of observation group was statistically significantly better than that of control group(P < 0. 05). No statistically significant differences of PLT,FIB,PT,TT,APTT,TXB2 or 6 - K - PGF1α was found between the two groups before treatment(P > 0. 05);after treatment,PLT,FIB and 6 - K - PGF1α of observation group were statistically significantly higher than those of control group,PT was of observation group was statistically significantly shorter than that of control group,TT and APTT were statistically significantly longer than those of control group,TXB2 of observation group was statistically significantly lower than that of control group( P < 0. 05 ). Only one case of control group occurred mild gastrointestinal discomfort,which spontaneously relieved. Conclusion Sodium ozagrel combined with aspirin is effective and safe in treating acute cerebral infarction,which can effectively relieve the neurological function defect symptoms,improve the clinical effect and inhibit platelet aggregation.