哮喘新生儿脐带血炎性因子水平变化及其临床意义

摘要

目的：分析哮喘新生儿脐带血炎性因子水平变化及其临床意义。方法选取2012—2015年内蒙古医科大学附属医院收治的哮喘孕妇60例作为研究组，另选取同期内蒙古医科大学附属医院收治的健康孕妇60例作为对照组。比较两组新生儿脐带血炎性因子〔白介素18、白介素5、白介素10、白介素1、白介素6、肿瘤坏死因子α（TNF-α）〕水平、新生儿哮喘发生情况及研究组哮喘新生儿与无哮喘新生儿脐带血炎性因子水平。结果研究组新生儿脐带血白介素18、白介素5、白介素1、白介素6、TNF-α水平高于对照组，脐带血白介素10水平低于对照组（P ﹤0.05）。研究组新生儿哮喘发生率高于对照组（P ﹤0.05）。研究组哮喘新生儿脐带血白介素18、白介素5、白介素1、白介素6、TNF-α水平高于无哮喘新生儿，脐带血白介素10水平低于无哮喘新生儿（P ﹤0.05）。结论哮喘新生儿脐带血炎性因子水平较高，早期检测新生儿脐带血炎性因子水平并采取有针对性的干预措施有助于减少新生儿哮喘的发生。%Objective To analyze the change and clinical significance of umbilical cord blood inflammatory cytokines levels in neonates with asthma. Methods A total of 60 pregnant women with asthma were selected as study group in the Affiliated Hospital of Inner Mongolia Medical University from 2012 to 2015,a total of 60 healthy pregnant women were selected as control group at the same time. Umbilical cord blood inflammatory cytokines(including IL-18,IL-5,IL-10,IL-1,IL-6 and TNF-α)levels were compared between the two groups,in neonates with asthma and without asthma,and incidence of asthma was compared between the two groups,too. Results Umbilical cord blood levels of IL-18,IL-5,IL-1,IL-6 and TNF-α of neonates of study group were statistically significantly higher than those of control group,while umbilical cord blood IL-10 level of neonates of study group was statistically significantly lower than that of control group(P ﹤ 0. 05). The incidence of asthma of neonates of study group was statistically significantly higher than that of control group(P ﹤ 0. 05). Of study group,umbilical cord blood levels of IL-18,IL-5,IL-1,IL-6 and TNF-α of neonates with asthma were statistically significantly higher than those of neonates without asthma,while umbilical cord blood IL-10 level of neonates with asthma was statistically significantly lower than that of neonates without asthma(P ﹤ 0. 05). Conclusion Umbilical cord blood inflammatory cytokines levels of neonates with asthma are significantly elevated,early detection of umbilical cord blood inflammatory cytokines levels of neonates and carrying out targeted intervention measures are helpful to reduce the incidence of asthma.