Objective To investigate the influencing factors of prognosis of inoperable patients with locally advanced non - small - cell lung cancer( NSCLC). Methods A total of 110 inoperable patients with locally advanced NSCLC were selected in Xiangyang Central Hospital Affiliated to Hubei Liberal Arts College from January 2000 to January 2007,all of them were followed up at the beginning of treatment until to 2015 - 01 - 31,the influencing factors of prognosis were analyzed. Results No statistically significant differences of cumulative survival rate was found in patients with different gender,with different age,with different clinical staging,with different PLT,with anemia or not(P ﹥ 0. 05),while there were statistically significant differences of cumulative survival rates in patients with smoking history or not,with different KPS score,received chemotherapy/ radiotherapy or not,with different WBC( P ﹤ 0. 05). Cox proportional hazard model analysis results showed that,smoking history〔 RR = 1. 157,95% CI( 1. 116,1. 213 )〕,KPS score equal or over 70 〔 RR = 1. 257,95% CI (1. 129,1. 294)〕,chemotherapy〔RR = 1. 165,95% CI(1. 124,1. 229)〕,WBC equal or over 10 × 109 / L〔RR = 1. 049, 95% CI(1. 035,1. 084)〕 were influencing factors of prognosis of inoperable patients with locally advanced NSCLC( P ﹤0. 05). Conclusion Smoking history,KPS score equal or over 70,chemotherapy,WBC equal or over 10 × 109 / L are influencing factors of prognosis of inoperable patients with locally advanced NSCLC.%目的：探讨不可手术局部晚期非小细胞肺癌（NSCLC）患者预后的影响因素。方法选取2000年1月—2007年1月湖北文理学院附属襄阳市中心医院收治的不可手术局部晚期 NSCLC 患者110例，于开始治疗时进行随访，随访截止时间为2015-01-31，分析其预后影响因素。结果不同性别、年龄、临床分期、血小板计数（PLT）及是否贫血患者累积生存率比较，差异无统计学意义（P ﹥0.05）；有无吸烟史、不同 KPS 评分、是否化疗或放疗、不同白细胞计数（WBC）患者累积生存率比较，差异有统计学意义（ P ﹤0.05）。Cox 比例风险回归模型分析结果显示，吸烟史〔RR =1.157，95% CI（1.116，1.213）〕、KPS 评分≥70分〔 RR =1.257，95% CI（1.129，1.294）〕、化疗〔RR =1.165，95% CI（1.124，1.229）〕、WBC≥10×109/ L〔RR =1.049，95% CI（1.035，1.084）〕是不可手术局部晚期 NSCLC 患者预后的影响因素（P ﹤0.05）。结论吸烟史、KSP 评分≥70分、化疗、WBC≥10×109/ L 是不可手术局部晚期 NSCLC 患者预后的影响因素。
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