Objective To investigate the application effect of creatine phosphate sodium for injection combined with coenzyme complex in the prevention and treatment of anthracyclines - induced myocardial damage in children with malignant tumor. Methods From January 2012 to January 2015,a total of 110 children with malignant tumor were selected in the People's Hospital of Jingshan County,and they were randomly divided into control group(n = 58) and observation group(n = 52). Children of the two groups received anthracyclines - based chemotherapy regimen,meanwhile children of control group were given extra creatine phosphate sodium for injection,while children of observation group were given creatine phosphate sodium for injection combined with coenzyme complex;both groups received 6 to 8 cycles of chemotherapy and 1 - week adjuvant therapy. Laboratory examination results( including hs-CRP,CK,CK-MB,LDH,α-HBDH,MDA and cTnT),index of cardiac function( including LVEF and CO) before and after treatment,and incidence of electrocardiographic abnormality (including arrhythmia,atrioventricular block and ST segment - T wave abnormality). Results No statistically significant differences of serum level of hs-CRP,CK,CK-MB,LDH,α-HBDH,MDA or cTnT was found between the two groups before treatment(P ﹥ 0. 05),nor was serum level of hs-CRP or CK was found between the two groups after treatment(P ﹥ 0. 05), while serum levels of CK-MB,LDH,α-HBDH,MDA and cTnT of observation group were statistically significantly lower than those of control group after treatment(P ﹤ 0. 05). No statistically significant differences of LVEF or CO was found between the two groups before treatment( P ﹥ 0. 05),while LVEF and CO of observation group were statistically significantly higher than those of control group after treatment(P ﹤ 0. 05). The incidence of electrocardiographic abnormality of observation group was statistically significantly lower than that of control group( P ﹤ 0. 05). Conclusion Creatine phosphate sodium for injection combined with coenzyme complex has good application effect in the prevention and treatment of anthracyclines - induced myocardial damage in children with malignant tumor,can effectively protect the myocardial cells,improve the cardiac function, maintain the stable myocardial cell electrophysiological properties and reduce the incidence of electrocardiographic abnormality.%目的：探讨注射用磷酸肌酸钠联合注射用复合辅酶对蒽环类药物所致恶性肿瘤患儿心肌损伤的防治效果。方法选取2012年1月—2015年1月京山县人民医院肿瘤科收治的恶性肿瘤患儿110例，随机分为对照组58例和观察组52例。两组患儿均予以蒽环类药物为基础的化疗方案，同时对照组患儿予以注射用磷酸肌酸钠辅助治疗，观察组患儿在对照组基础上加用注射用复合辅酶辅助治疗；连续化疗6~8个化疗周期，辅助治疗1周。比较两组患儿治疗前后实验室检查指标〔超敏 C 反应蛋白（ hs-CRP）、肌酸激酶（ CK）、肌酸激酶同工酶（ CK-MB）、乳酸脱氢酶（LDH）、α-羟丁酸脱氢酶（α-HBDH）、丙二醛（MDA）、心肌肌钙蛋白 T（cTnT）〕，心功能指标〔左心室射血分数（LVEF）、心排出量（CO）〕，心电图异常（心律失常、房室传导阻滞、ST 段- T 波改变）发生情况。结果治疗前两组患儿血清hs-CRP、CK、CK-MB、LDH、α-HBDH、MDA、cTnT 水平比较，差异无统计学意义（P ﹥0.05）；治疗后两组患儿血清hs-CRP、CK 水平比较，差异无统计学意义（P ﹥0.05），观察组患儿血清CK-MB、LDH、α-HBDH、MDA、cTnT 水平低于对照组（P ﹤0.05）。治疗前两组患儿 LVEF、CO 比较，差异无统计学意义（P ﹥0.05）；治疗后观察组患儿 LVEF、CO 高于对照组（P ﹤0.05）。观察组患儿心电图异常发生率低于对照组（P ﹤0.05）。结论注射用磷酸肌酸钠联合注射用复合辅酶对蒽环类药物所致恶性肿瘤患儿心肌损伤具有良好的防治效果，可有效保护患儿心肌细胞，改善患儿心功能，稳定心肌细胞电生理特性，降低心电图异常发生率。
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