阿托伐他汀钙片联合苯磺酸氨氯地平片治疗冠心病的临床疗效观察

摘要

目的：观察阿托伐他汀钙片联合苯磺酸氨氯地平片治疗冠心病的临床疗效。方法选取2015年4—12月榆林市第一医院绥德医院心内科收治的冠心病患者84例，按随机数字表法分为对照组与观察组，每组42例。对照组患者予以苯磺酸氨氯地平片治疗，观察组患者在对照组基础上加用阿托伐他汀钙片治疗；两组患者均连续治疗4周。比较两组患者临床疗效、治疗前后 N 端脑钠肽前体（NT-proBNP）、纤维蛋白原（FIB）、超敏 C 反应蛋白（hs-CRP）和心功能指标〔左心室射血分数（LVEF）、左心室舒张末期内径（LVEDD）、左心室后壁厚度（LVPWd）〕及不良反应发生情况。结果观察组患者临床疗效优于对照组（P <0.05）。治疗前两组患者血浆NT-proBNP、FIB、hs-CRP水平比较，差异无统计学意义（P >0.05）；治疗后观察组患者血浆NT-proBNP、FIB、hs-CRP水平低于对照组（P <0.05）。治疗前两组患者 LVEF、LVEDD、LVPWd 比较，差异无统计学意义（P >0.05）；治疗后观察组患者 LVEF 高于对照组， LVEDD、LVPWd 小于对照组（P <0.05）。两组患者不良反应发生率比较，差异无统计学意义（P >0.05）。结论阿托伐他汀钙片联合苯磺酸氨氯地平片治疗冠心病的临床疗效确切，可有效改善患者临床症状，提高患者心功能。%Objective To observe the clinical effect of atorvastatin calcium tablets combined with amlodipine besylate tablets on coronary heart disease. Methods From April to December in 2015,a total of 84 patients with coronary heart disease were selected in the Department of Cardiology,Suide Hospital of the First Hospital of Yulin,and they were divided into control group and observation group according to random number table,each of 42 cases. Patients of control group received amlodipine besylate tablets,while patients of observation group received atorvastatin calcium tablets combined with amlodipine besylate tablets;both groups continuously treated for 4 weeks. Clinical effect,NT-proBNP,FIB,hs-CRP and index of cardiac function (including LVEF,LVEDD and LVPWd)before and after treatment,and incidence of adverse reactions were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group (P < 0. 05). No statistically significant differences of plasma level of NT-proBNP,FIB or hs-CRP was found between the two groups before treatment(P > 0. 05),while plasma levels of NT-proBNP,FIB and hs-CRP of observation group were statistically significantly lower than those of control group after treatment( P < 0. 05). No statistically significant differences of LVEF, LVEDD or LVPWd was found between the two groups before treatment(P > 0. 05);after treatment,LVEF of observation group was statistically significantly higher than that of control group,while LVEDD and LVPWd of observation group were statistically significantly smaller than those of control group( P < 0. 05). No statistically significant differences of incidence of adverse reactions was found between the two groups(P > 0. 05). Conclusion Atorvastatin calcium tablets combined with amlodipine besylate tablets has certain clinical effect in treating coronary heart disease,can effectively relieve the clinical symptoms and improve the cardiac function.