Objective To compare the clinical features and cognitive function between patients with P - type multiple system atrophy and patients with Parkinson′s disease. Methods From July 2012 to August 2014 in the Central Hospital of China Petroleum and Natural Gas Corporation,a total of 31 patients with P - type multiple system atrophy were selected as A group,53 patients with Parkinson′s disease were selected as B group. Clinical features,motor function,daily behavior ability,cognitive function,mentality and memory were compared between the two groups. Results No statistically significant differences of incidence of mental retardation was found between the two groups( P > 0. 05);incidence of initial tremor and extrapyramidal symptoms of A group was statistically significantly lower than that of B group,respectively,while incidence of mobility limitation,linguistic barrier, cerebellum symptoms, pyramidal tract symptoms, sexual dysfunction, paruria and postural hypotension,and ineffective rate of madopar of A group was statistically significantly higher than that of B group(P < 0. 05). UPDRS - Ⅲ scores and ADL scores of A group were statically significantly higher than those of B group(P < 0. 05). MMSE score of A group was statistically significantly lower than that of B group(P < 0. 05). No statistically significant differences of naming score,attentiveness score,language score,abstract ability score,memory score,directive force score and total MoCA score was found between the two groups(P > 0. 05),while visual space/ executive function score of A group was statistically significantly lower than that of B group(P < 0. 05). Operating Scale score of A group was statistically significantly lower than that of B group(P < 0. 05),while no statistically significant differences of total WAIS-RC score or Verbal Scale score was found between the two groups(P > 0. 05). No statistically significant differences of visual recognition score,similarity score or digit span score was found between the two groups( P > 0. 05);while visual reproduction score,comprehension memory score, graphic arrangement score,building test score and total Wechsler Adults Memory Scale score of A group were statistically significantly lower than those of B group( P < 0. 05). Conclusion There are significant differences of clinical features and cognitive function between patients with P - type multiple system atrophy and patients with Parkinson′ s disease,cognitive function,mentality and memory of patients with P - type multiple system atrophy are worse than those of patients with Parkinson′s disease.%目的：比较多系统萎缩 P 型（MSA-P 型）与帕金森病患者的临床特征及认知功能。方法选取2012年7月—2014年8月中国石油天然气总公司中心医院收治的 MSA-P 型患者31例作为 A 组，帕金森病患者53例作为 B组。比较两组患者临床特征、运动功能、日常行为能力、认知功能、智力及记忆力。结果两组患者智能障碍发生率比较，差异无统计学意义（P >0.05）；A 组患者首发震颤发生率、锥体外系症状发生率低于 B 组，行走困难发生率、语言障碍发生率、小脑症状发生率、美多巴治疗无效率、锥体束症状发生率、性功能异常发生率、排尿异常发生率、直立性低血压发生率高于 B 组（P <0.05）。A 组患者帕金森综合评分量表Ⅲ（UPDRS-Ⅲ）评分、日常生活活动能力量表（ADL）评分高于 B 组（P <0.05）。A 组简易智能精神状态检查量表（MMSE）评分低于 B 组（P <0.05）。两组患者命名评分、注意力评分、语言评分、抽象能力评分、记忆评分、定向力评分及蒙特利尔认知评估量表（ MoCA）总评分比较，差异无统计学意义（P >0.05）；A 组患者视空间/执行功能评分低于 B 组（P <0.05）。A 组患者操作量表评分低于 B 组（P <0.05）；两组患者中国修订韦氏成人智力量表（WAIS-RC）总评分、言语量表评分比较，差异无统计学意义（P >0.05）。两组患者视觉再认评分、相似性评分、数字广度评分比较，差异无统计学意义（P >0.05）；A 组患者视觉再生评分、理解记忆评分、图形排列评分、积木测试评分、韦氏成人记忆量表总评分低于 B 组（ P <0.05）。结论 MSA-P 型与帕金森病患者临床特征及认知功能存在差异，与帕金森病患者比较，MSA-P 型患者认知功能、智力及记忆力较差。
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