Objective To observe the clinical effect of xuezhikang capsule combined with amlodipine atorvastatin calcium tablet in treating hypertension patients complicated with coronary heart disease,to investigate the impact on blood lipids, vascular endothelial function and inflammation. Methods A total of 102 hypertension patients complicated with coronary heart disease were selected in the Second Affiliated Hospital of Nanyang Medical Technical College,and they were divided into control group and observation group according to random number table,each of 51 cases. Patients of control group were given amlodipine atorvastatin calcium tablet,while patients of observation group were given xuezhikang capsule combined with amlodipine atorvastatin calcium tablet;both groups continuously treated for 3 months. Clinical effect,blood pressure,blood lipids index, serum inflammatory cytokines levels and index of vascular endothelial function before and after treatment were compared between the two groups,and the incidence of adverse reactions was observed during the treatment. Results The clinical effect of observation group was statistically significantly better than that of control group ( P < 0. 05 ). No statistically significant differences of SDP or SBP was found between the two groups before treatment(P > 0. 05),while SDP and SBP of observation group were statistically significantly lower than those of control group after treatment( P < 0. 05). No statistically significant differences of serum level of LDL-C,HDL-C,TC or TG was found between the two groups before treatment(P > 0. 05);after treatment,serum levels of LDL-C,TC and TG of observation group were statistically significantly lower than those of control group,while serum HDL-C level of observation group was statistically significantly higher than that of control group(P < 0. 05). No statistically significant differences of serum level of CRP,TNF-α or IL-6 was found between the two groups before treatment (P > 0. 05),while serum levels of CRP,TNF-α and IL-6 of observation group were statistically significantly lower than those of control group after treatment(P < 0. 05). No statistically significant differences of plasma level of ET-1 or NO was found between the two groups before treatment ( P > 0. 05 );after treatment,plasma ET-1 level of observation group was statistically significantly lower than that of control group,while plasma NO level of observation group was statistically significantly higher than that of control group( P < 0. 05). No one of the two groups occurred any serious adverse reactions during the treatment. Conclusion Xuezhikang capsule combined with amlodipine atorvastatin calcium tablet has certain clinical effect in treating hypertension patients complicated with coronary heart disease, can effectively reduce the blood pressure, relieve the inflammation,adjust the blood lipid metabolism and improve the vascular endothelial function,and has relatively high safety.%目的：观察血脂康胶囊联合氨氯地平阿托伐他汀钙片治疗高血压并冠心病的临床疗效，探讨其对血脂、血管内皮功能及炎症的影响。方法选取2013年7月—2015年7月南阳医专第二附属医院收治的高血压并冠心病患者102例，按照随机数字表法分为对照组和观察组，每组51例。对照组患者给予氨氯地平阿托伐他汀钙片治疗，观察组患者给予血脂康胶囊联合氨氯地平阿托伐他汀钙片治疗；两组患者疗程均为3个月。比较两组患者临床疗效，治疗前后血压、血脂指标、血清炎性因子水平及血管内皮功能指标，并观察治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组（P <0.05）。治疗前两组患者舒张压和收缩压比较，差异无统计学意义（P >0.05）；治疗后观察组患者舒张压和收缩压均低于对照组（P <0.05）。治疗前两组患者血清低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）、三酰甘油（TG）水平比较，差异无统计学意义（P >0.05）；治疗后观察组患者血清LDL-C、TC、TG 水平低于对照组，血清HDL-C水平高于对照组（P <0.05）。治疗前两组患者血清 C 反应蛋白（CRP）、肿瘤坏死因子α（TNF-α）、白介素6（IL-6）水平比较，差异无统计学意义（P >0.05）；治疗后观察组患者血清 CRP、TNF-α、IL-6水平低于对照组（P <0.05）。治疗前两组患者血浆内皮素1（ET-1）和一氧化氮（NO）水平比较，差异无统计学意义（P >0.05）；治疗后观察组患者血浆ET-1水平低于对照组，血浆 NO 水平高于对照组（P <0.05）。两组患者治疗期间均未发生严重不良反应。结论血脂康胶囊联合氨氯地平阿托伐他汀钙片治疗高血压并冠心病的临床疗效确切，能有效降低患者血压，改善血脂代谢、血管内皮功能及炎症状态，且安全性较高。
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