Objective To analyze the influencing factors of acute carbon monoxide poisoning delayed encephalopathy. Methods From January 2008 to April 2015,a total of 340 patients with acute carbon monoxide poisoning were selected in the People′s Hospital of Tang County,and they were divided into A group(complicated with delayed encephalopathy,n = 40)and B group(did not complicated with delayed encephalopathy,n = 270)according to the incidence of delayed encephalopathy. The clinical data of the two groups was retrospectively analyzed,including general information,laboratory examination results and clinical manifestations,and the influencing factors of acute carbon monoxide poisoning delayed encephalopathy were analyzed. Results No statistically significant differences of gender,BMI,coexistent disease,carbon monoxide contacting time,abnormal rate of EEG,treatment time or therapeutic times of hyperbaric oxygen was found between the two groups(P > 0. 05),while age of A group was statistically significantly elder than that of B group,duration of coma and pseudo - recovery period of A group were statistically significantly longer than those of B group( P < 0. 05 ) . No statistically significant differences of SBP,DBP, respiratory rate or pulse was found between the two groups(P > 0. 05),while blood lactic acid level of A group was statistically significantly higher than that of B group(P < 0. 05). Multivariate logistic regression analysis showed that,below 60 years old〔OR = 0. 432,95% CI(0. 111,0. 389)〕,duration of coma less than 10 hours〔OR = 0. 689,95% CI(0. 294,0. 782)〕, duration of pseudo - recovery period less than 4 hours〔OR = 0. 277,95% CI(0. 111,0. 892)〕and blood lactic acid level less than 5 mmol/ L〔OR = 0. 289,95% CI(0. 211,0. 833)〕were protective factors of acute carbon monoxide poisoning delayed encephalopathy(P < 0. 05). The incidence of dementia,gatism,movement out of control and lags in response of A group was statistically significantly higher than that of B group,respectively( P < 0. 05 ). Conclusion Patients with acute carbon monoxide poisoning have high risk of delayed encephalopathy,which can results in dysneuria,age,duration of coma and pseudo- recovery period,and blood lactic acid level are influencing factors of acute carbon monoxide poisoning delayed encephalopathy.%目的：分析急性一氧化碳中毒迟发性脑病的影响因素。方法选取2008年1月—2015年4月唐县人民医院收治的急性一氧化碳中毒患者340例，根据是否发生迟发性脑病分为急性一氧化碳中毒迟发性脑病组（A 组）70例与急性一氧化碳中毒非迟发性脑病组（B 组）270例。回顾性分析两组患者的临床资料（包括一般资料、实验室检查指标、临床表现等），分析急性一氧化碳中毒迟发性脑病的影响因素。结果两组患者性别、体质指数、合并疾病、一氧化碳接触时间、脑电图异常发生率、高压氧治疗时间、高压氧治疗次数比较，差异无统计学意义（ P >0.05）；A 组患者年龄大于 B 组，昏迷时间、假愈期时间长于 B 组（ P <0.05）。两组患者收缩压（ SBP）、舒张压（DBP）、呼吸频率、脉搏比较，差异无统计学意义（P >0.05）；A 组患者血乳酸水平高于 B 组（P <0.05）。多因素logistic 回归分析结果显示，年龄<60岁〔OR =0.432，95% CI（0.111，0.389）〕、昏迷持续时间<10 h〔OR =0.689，95% CI（0.294，0.782）〕、假愈期时间<4 h〔OR =0.277，95% CI（0.111，0.892）〕和血乳酸水平<5 mmol/ L〔OR=0.289，95% CI（0.211，0.833）〕是急性一氧化碳中毒患者发生迟发性脑病的保护因素（ P <0.05）。A 组患者痴呆、大小便失禁、运动失控、反应迟钝发生率高于 B 组（P <0.05）。结论急性一氧化碳中毒患者易发生迟发性脑病会导致患者神经功能障碍，年龄、昏迷持续时间、假愈期时间和血乳酸水平是急性一氧化碳中毒迟发性脑病的影响因素。
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