可溶性 CD40配体与心脑血管疾病关系的研究进展

摘要

sCD40L is one kind of transmembrane glycoproteins,belongs to tumor necrosis factor family,comes from proteolytic enzyme - induced cracking of mCD40L,mainly performs as tripolymer. Recent research found that,sCD40L can increase the risk of atherosclerosis,is closely correlated with cardiac - cerebral vascular disease. This paper reviewed the correlations of sCD40L with atherosclerosis,cardiovascular disease and cerebrovascular disease,in order to provide new clew for the prevention and treatment of cardiac - cerebral vascular disease.%可溶性 CD40配体（sCD40L）是一种跨膜糖蛋白，属肿瘤坏死因子家族，其是由 mCD40L 在蛋白水解酶的作用下裂解而成，并以三聚体的形式存在。有研究发现，sCD40L 可增加动脉粥样硬化发生风险，且与心脑血管疾病的发生发展密切相关。本文综述了 sCD40L 与动脉粥样硬化、心血管疾病及脑血管疾病关系的研究进展，旨在为心脑血管疾病的防治提供新的思路。