首页> 中文期刊> 《实用心脑肺血管病杂志》 >苦碟子注射液对脑梗死恢复期患者血液流变学的影响研究

苦碟子注射液对脑梗死恢复期患者血液流变学的影响研究

摘要

Objective To observe the impact of kudiezi injection on hemorheology of recovery phase patients with cerebral infarction. Methods From June 2013 to June 2015,a total of 92 recovery phase patients with cerebral infarction were selected in the Department of Neurology,the Central Hospital of Huanggang,and they were randomly divided into control group and treatment group,each of 46 cases. patients of control group were given aspirin enteric - coated tablets combined with atorvastatin calcium tablets after admission,while patients of treatment group were given extra kudiezi injection based on the treatment of control group;both groups continuously treated for 2 weeks. Hemodynamic index(including whole low - shear blood viscosity,whole high - shear blood viscosity,plasma viscosity,whole blood reductive viscosity and platelet aggregation index) and NIHSS score before treatment and after treatment were compared between the two groups. Results Of treatment group,2 cases retreated from this study because of rash,1 case retreated from this study because of palpitation,2 cases quit at midway;of control group,1 case retreated from this study because of nausea and vomiting,2 cases quit at midway. No statistically significant differences of whole low - shear blood viscosity,whole high - shear blood viscosity,plasma viscosity,whole blood reductive viscosity or platelet aggregation index was found between the two groups before treatment(P > 0. 05);while whole low- shear blood viscosity,whole high - shear blood viscosity,plasma viscosity,whole blood reductive viscosity and platelet aggregation index of treatment group were statistically significantly lower than those of control group after treatment(P < 0. 05). No statistically significant differences of NIHSS was found between the two groups before treatment(P > 0. 05),while NIHSS score of treatment group was statistically significantly lower than that of control group after treatment(P < 0. 05). Conclusion Kudiezi injection can effectively improve the hemorheology and neurological function of recovery phase patients with cerebral infarction.%目的:观察苦碟子注射液对脑梗死恢复期患者血液流变学的影响。方法选取黄冈市中心医院神经内科2013年6月—2015年6月收治的脑梗死恢复期患者92例,随机分为治疗组和对照组,每组46例。对照组患者采用阿司匹林肠溶片联合阿托伐他汀钙片治疗,治疗组患者在对照组基础上给予苦碟子注射液治疗;两组患者均治疗2周。比较两组患者治疗前后血液流变学指标(全血低切黏度、全血高切黏度、血浆黏度、全血还原黏度、血小板聚集指数)、美国国立卫生研究院卒中量表(NIHSS)评分。结果治疗组共完成治疗41例,其中分别因皮疹、心悸退出本研究2例、1例,中途退出研究2例;对照组共完成治疗43例,其中因恶心呕吐退出本研究1例,中途退出2例。两组患者治疗前全血低切黏度、全血高切黏度、血浆黏度、全血还原黏度、血小板聚集指数比较,差异无统计学意义(P >0.05);治疗组患者治疗后全血低切黏度、全血高切黏度、血浆黏度、全血还原黏度、血小板聚集指数低于对照组(P <0.05)。两组患者治疗前 NIHSS 评分比较,差异无统计学意义(P >0.05);治疗组患者治疗后 NIHSS 评分低于对照组(P <0.05)。结论苦碟子注射液能有效改善脑梗死恢复期患者的血液流变学及神经功能。

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