Objective To investigate the impact of tongxinluo capsule on inflammatory cytokines and carotid atherosclerostic plaques of hypertension patients complicated with carotid artery atherosclerosis. Methods From March 2014 to March 2015,a total of 100 hypertension patients complicated with carotid artery atherosclerosis were selected in the Department of Geriatrics,the Affiliated Luhe Hospital of Capital Medical University,and they were divided into control group and observation group according to random number table,each of 50 cases. patients of both groups were given conventional medical treatment, while patients of observation group received extra tongxinluo capsule;both groups treated for 12 weeks at least. SBp,DBp, CRp,IL-6,VEGF,NO,IMT and plaque area of carotid artery before and after treatment were compared between the two groups,and incidence of adverse reactions during treatment was observed. Results No statistically significant differences of SBp or DBp was found between the two group before or after treatment(P > 0. 05). No statistically significant differences of serum level of CRp or IL-6 was found between the two groups before treatment(P > 0. 05),while serum levels of CRp and IL-6 of observation group were statistically significantly lower than those of control group after treatment(P < 0. 05). No statistically significant differences of VEGF,NO,IMT or plaque area of carotid artery was found between the two groups before treatment(P> 0. 05);after treatment,IMT and plaque area of carotid artery of observation group were statistically significantly smaller than those of control group,while VEGF and NO of observation group were statistically significantly higher than those of control group (P < 0. 05). No one of the two groups occurred any drug - related adverse reactions,or dropped out. Conclusion Tongxinluo capsule can effectively reduce the inflammatory cytokines,improve the vascular endothelial function and shrink the carotid atherosclerostic plaques of hypertension patients complicated with carotid artery atherosclerosis.%目的：探讨通心络胶囊对高血压合并颈动脉粥样硬化患者炎性因子及颈动脉粥样硬化斑块的影响。方法选取2014年3月—2015年3月首都医科大学附属北京潞河医院老年病科门诊收治的高血压合并颈动脉粥样硬化患者100例，按照随机数字表法分为观察组和对照组，各50例。两组患者均给予常规药物治疗，观察组患者在常规药物治疗基础上加服通心络胶囊，两组患者口服药物至少维持12周。比较两组患者治疗前后血压（收缩压、舒张压）、炎性因子〔C 反应蛋白（ CRp）和白介素6（ IL-6）〕、血管内皮功能指标〔血管内皮生长因子（ VEGF）、一氧化氮（NO）〕及颈动脉斑块情况〔内膜中层厚度（IMT）和斑块面积〕，观察两组患者治疗期间不良反应发生情况。结果两组患者治疗前后收缩压和舒张压比较，差异无统计学意义（P >0.05）。治疗前两组患者血清 CRp 和 IL-6水平比较，差异无统计学意义（P >0.05）；治疗后观察组患者血清 CRp 和 IL-6水平低于对照组（P <0.05）。治疗前两组患者VEGF、NO、颈动脉 IMT 及斑块面积比较，差异无统计学意义（ P >0.05）；治疗后观察组患者 VEGF、NO 高于对照组，颈动脉 IMT、斑块面积小于对照组（P <0.05）。治疗期间两组患者均未出现药物不良反应，未出现脱落病例。结论通心络胶囊能明显降低高血压合并颈动脉粥样硬化患者炎性因子水平，改善血管内皮功能及颈动脉粥样硬化斑块。
展开▼
