血清白介素17及干扰素γ水平与急性冠脉综合征患者心功能的相关性研究

摘要

Objective To investigate the correlations of serum levels of IL-17 and INF-γ with cardiac function of patients with acute coronary syndrome.Methods From January 2014 to January 2017,a total of 62 patients with acute coronary syndrome were selected in the Department of Cardiology,the Fourth People's Hospital of Changzhou,and they were divided into A group (with acute myocardial infarction) and B group (with unstable angina pectoris) according to illness types,each of 31 cases;meanwhile a total of 31 healthy people admitted to this hospital for physical examination were selected as control group.Serum levels of IL-17 and INF-γ and index of cardiac function were compared among the three groups,Pearson correlation analysis was used to analyze the correlations of serum levels of IL-17 and INF-γ with index of cardiac function in patients with acute coronary syndrome and in patients with acute myocardial infarction.Results Serum levels of IL-17 and INF-γof A group and B group were statistically significantly higher than those of control group,meanwhile serum INF-γ level of A group was statistically significantly higher than that of B group (P ＜ 0.05).LVEF and LVFS of A group were statistically significantly lower than those of control group and B group,while LVEDD of A group were statistically significantly longer than those of control group and B group (P ＜0.05).Pearson correlation analysis results showed that,serum IL-17 was negatively correlated with LVEF of patients with acute coronary syndrome (r =-0.301,P ＜ 0.05);serum IL-17 was negatively correlated with LVEF of patients with acute myocardial infarction (r =-0.523,P ＜0.05),meanwhile serum INF-γlevel was negatively correlated with LVEF (r=-0.125) and LVEDD (r =-0.011) of patients with acute myocardial infarction,respectively (P ＜ 0.05).Conclusion Serum levels of IL-17 and INF-γare significantly correlated with cardiac function of patients with acute coronary syndrome,can reflect the severity of ACS to some extent.%目的 探讨血清白介素17及干扰素γ水平与急性冠脉综合征(ACS)患者心功能的相关性.方法 选取2014年1月-2017年1月常州市第四人民医院心内科收治的ACS患者62例,根据疾病类型分为A组[急性心肌梗死(AMI)]与B组[不稳定型心绞痛(UAP)],每组31例;另选取同期于常州市第四人民医院体检健康者31例作为对照组.比较3组受试者血清白介素17和干扰素γ水平及心功能指标;血清白介素17、干扰素γ水平与ACS、AMI患者心功能指标的相关性分析采用Pearson相关性分析.结果 A、B组患者血清白介素17、干扰素γ水平高于对照组(P＜0.05);A组患者血清干扰素γ水平高于B组(P＜0.05).A组患者左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)低于对照组、B组,左心室舒张末期内径(LVEDD)长于对照组、B组(P＜0.05).Pearson相关性分析结果显示,血清白介素17水平与ACS患者LVEF呈负相关(r=-0.301,P＜0.05);血清白介素17水平与AMI患者LVEF呈负相关(r=-0.523,P＜0.05),血清干扰素γ水平与AMI患者LVEF、LVEDD呈负相关(r值分别为-0.125、-0.011,P＜0.05).结论 血清白介素17及干扰素γ水平与ACS患者心功能密切相关,可在一定程度上反映ACS患者病情严重程度.