Objective To observe the clinical effect of carthamin yellow injection combined with batroxobin injection on acute sub-massive pulmonary embolism(ASPE)in elderly patients with non-small cell lung cancer(NSCLC).Methods A total of 202 elderly NSCLC patients complicated with ASPE were selected in the First People's Hospital of Xianyang from January 2016 to January 2017,and they were divided into control group and treatment group according to random number table, each of 101 cases. Based on conventional treatment,patients in control group received batroxobin injection,while patients in treatment group received carthamin yellow injection combined with batroxobin injection;both groups continuously treated for 14 days. Clinical effect,arterial blood-gas analysis,index of blood coagulation function and right heart function before and after treatment were compared between the two groups,and incidence of adverse reactions was observed during treatment.Results Clinical effect in treatment group was statistically significantly better than that in control group(P<0.05). No statistically significant differences of PaCO2,P(A-a)O2 or PaO2 was found between the two groups before treatment(P>0.05);after treatment,PaCO2 and P(A-a)O2 in treatment group were statistically significantly lower than those in control group,while PaO2 in treatment group was statistically significantly higher than that in control group(P<0.05). No statistically significant differences of D-dimer,cTnI,PT or APTT was found between the two groups before treatment(P>0.05);after treatment,D-dimer and cTnI in treatment group were statistically significantly lower than those in control group,meanwhile PT and APTT in treatment group were statistically significantly shorter than those in control group(P<0.05). No statistically significant differences of right atrial inner diameter,PGTI,pulmonary arterial pressure or right ventricle diameter was found between the two groups before treatment(P>0.05);after treatment,right atrial inner diameter and right ventricle diameter in treatment group were statistically significantly shorter than those in control group,meanwhile PGTI and pulmonary arterial pressure in treatment group were statistically significantly lower than those in control group(P<0.05). No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment(P>0.05).Conclusion Carthamin yellow injection combined with batroxobin injection has certain clinical effect on ASPE in elderly patients with NSCLC,can effectively adjust the arterial blood-gas analysis,improve the blood coagulation function and right heart function,and is relatively safe.%目的 观察红花黄色素注射液联合巴曲酶注射液治疗老年非小细胞肺癌(NSCLC)并急性次大面积肺栓塞(ASPE)的临床疗效.方法 选取2016年1月—2017年1月咸阳市第一人民医院收治的老年NSCLC并ASPE患者202例,采用随机数字表法分为对照组和治疗组,每组101例.在常规治疗基础上,对照组患者给予巴曲酶注射液治疗,治疗组在对照组基础上给予红花黄色素注射液治疗;两组患者均连续治疗14 d.比较两组患者临床疗效,治疗前后动脉血气分析指标、凝血功能指标、右心功能指标,观察两组患者治疗期间不良反应发生情况.结果 治疗组患者临床疗效优于对照组(P<0.05).治疗前两组患者动脉血二氧化碳分压(PaCO2)、肺泡-动脉血氧分压差〔P(A-a)O2〕、动脉血氧分压(PaO2)比较,差异无统计学意义(P>0.05);治疗后治疗组患者PaCO2、P(A-a)O2低于对照组,PaO2高于对照组(P<0.05).治疗前两组患者D-二聚体、心肌肌钙蛋白I(cTnI)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)比较,差异无统计学意义(P>0.05);治疗后治疗组患者D-二聚体、cTnI低于对照组,PT、APTT短于对照组(P<0.05).治疗前两组患者右心房内径、右心房室瓣反流压差、肺动脉压及右心室内径比较,差异无统计学意义(P>0.05);治疗后治疗组患者右心房内径、右心室内径短于对照组,右房室瓣反流压差、肺动脉压低于对照组(P<0.05).两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05).结论 红花黄色素注射液联合巴曲酶注射液治疗老年NSCLC并ASPE患者的临床疗效确切,可有效改善患者动脉血气指标、凝血功能、右心功能,且安全性较高.
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