Objective To observe the clinical effect of lactase on rotavirus enteritis in infants and young children. Methods From January 2015 to May 2017,a total of 120 infants and young children with rotavirus enteritis were selected in the Department of Pediatrics,Naval Authority Clinics,and they were divided into A group,B group and C group according to random number table,each of 40 cases.Based on conventional treatment,patients in A group kept customary diet,patients in B group received free-lactose milk powder for 2 weeks,while patients in C group kept customary diet and received lactase for 2 weeks.Clinical effect,diarrhea frequency before treatment and 4 days after treatment,and diarrhea stopping time were compared in the three groups,compliance and incidence of adverse reactions was observed in C group.Results Clinical effect in B group and C group was statistically significantly better than that in A group,respectively(P<0.05),while no statistically significant differences of clinical effect was found between B group and C group(P>0.05).No statistically significant differences of diarrhea frequency was found in the three groups before treatment(P>0.05);4 days after treatment,diarrhea frequency in B group and C group were statistically significantly less than that in A group,respectively(P<0.05),while no statistically significant differences of diarrhea frequency was found between B group and C group(P>0.05).Diarrhea stopping time in B group and C group was statistically significantly shorter than that in A group,respectively(P<0.05),while no statistically significant differences of diarrhea stopping time was found between B group and C group(P>0.05).The compliance was good in C group, no one occurred any obvious adverse reactions.Conclusion Lactase has similar clinical effect with free-lactose milk powder in treating infants and young children with rotavirus enteritis,can effectively relieve the lactose intolerance without change the customary diet,and the compliance is good.%目的 观察乳糖酶治疗婴幼儿轮状病毒肠炎的临床疗效.方法 选取2015年1月—2017年5月海军机关门诊部儿科诊治的轮状病毒肠炎患儿120例,采用随机数字表法分为对照组、无乳糖奶粉组和乳糖酶治疗组,每组40例.在常规治疗基础上,对照组患儿继续原饮食喂养,无乳糖奶粉组患儿改为无乳糖奶粉喂养并维持2周,乳糖酶治疗组患儿加用乳糖酶并维持2周.比较3组患儿临床疗效、治疗前及治疗第4天排便次数、止泻时间,观察乳糖酶治疗组患儿依从性及不良反应发生情况.结果 乳糖酶治疗组及无乳糖奶粉组患儿临床疗效均优于对照组(P<0.05),而乳糖酶治疗组与无乳糖奶粉组患儿临床疗效比较,差异无统计学意义(P>0.05).3组患儿治疗前排便次数比较,差异无统计学意义(P>0.05);乳糖酶治疗组及无乳糖奶粉组患儿治疗第4天排便次数少于对照组(P<0.05),而乳糖酶治疗组与无乳糖奶粉组患儿治疗第4天排便次数比较,差异无统计学意义(P>0.05).乳糖酶治疗组、无乳糖奶粉组患儿止泻时间短于对照组(P<0.05),而乳糖酶治疗组与无乳糖奶粉组患儿止泻时间比较,差异无统计学意义(P>0.05).乳糖酶治疗组患儿依从性较好,未出现明显不良反应.结论 乳糖酶与无乳糖喂养治疗婴幼儿轮状病毒肠炎的临床疗效相当,能有效改善患儿乳糖不耐受且不改变原饮食结构,依从性较好.
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