E3泛素连接酶调控植物抗病分子机理研究进展

摘要

Biotic stress is an important factor that affects crop production in China.It is also one of the most wide-ly studied areas in plant sciences.Degradation mediated by the ubiquitin proteasome system (UPS)is one of the most sophisticated regulation systems in eukaryotes,which is involved in plant growth and development and in re-sponse to abiotic and biotic stresses.E3 ligase is considered as a key enzyme in the UPS due to its specific interac-tions with its substrates.Based on the differences in structure and function,E3 ligases can be divided into four main classes.In this paper,we review the recent progresses in the regulation mechanism of E3 ligases in plant dis-ease resistance and propose new research directions.%生物胁迫是影响我国农作物生产的重要因素，也是当前植物界研究方向涉及最为广泛的领域之一。由泛素介导的降解途径是生物体内最为精细的调控体系，涉及对生物体的生长发育以及生物体对周围环境适应的调控等过程。E3泛素连接酶因对底物有特异性识别作用，被认为是泛素化过程中最重要的组成部分。依据其结构和功能的不同可以将 E3泛素连接酶分为4个家族。越来越多的研究表明这些不同的 E3家族成员可以参与植物抗病免疫反应的各个过程。本文在简要概括 E3泛素连接酶分类的基础上综述了目前 E3泛素连接酶参与调控植物抗病害方面研究进展，并对今后研究方向进行了展望，以期对抗病机理解析及抗病品种研发提供新思路。