鼠伤寒沙门菌动物模型活体成像技术的研究进展

摘要

Study on Salmonella typhimurium (S.typhimurium) pathogenesis in vivo is significant for control of food poisoning, gastroenteritis, typhoid fever and other intestinal infectious diseases.Because it is difficult to detect dynamic changes for S.typhimurium in living hosts, the strategy for preventation and treatment of Salmonellosis as well as the development of drug and vaccine production are restricted.In recent years, small animal imaging technology is widely used to track bioluminescent Salmonella typhimurium (S.typh-lux) in vivo.The present article summarizes the merit and shortage of the application of small animal imaging.%鼠伤寒沙门菌的体内实验有利于开展食物中毒、胃肠炎、伤寒热等肠道传染病的防治.由于在活体内检测鼠伤寒沙门菌的动态变化存在瓶颈,使细菌致病机制的研究、疫苗及药物研发滞后.近年来应用小动物成像技术在活体中追踪转化了荧光素酶基因的鼠伤寒沙门菌越来越受到人们关注,综述该技术的应用现状及缺憾之处.