Relationship of CD24 and CD2β molecule expression in cervical cancer tissues with cancer cell growth and their potential therapeutic value

摘要

cqvip:Objective:To investigate the relationship of CD24 and CD2β molecule expression in cervical cancer tissues with cancer cell growth and their potential therapeutic value.Methods: A total of 40 patients with cervical cancer underwent radical surgery, and the cervical cancer tissue samples and tissue samples adjacent to carcinoma were collected. The differences in CD24 and CD2β molecule expression in adjacent tissues and cervical cancer tissues were compared, and the correlation of CD24 and CD2β molecule expression in cervical cancer tissues with proliferation and apoptosis gene expression was further determined.Results: CD24 expression in cervical cancer tissues was higher than that in adjacent tissues whereas CD2β expression was lower than that in adjacent tissues. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD24 expression group were lower than those in low CD24 expression group whereas SCD-1, TLR4 and HERC4 mRNA expression were higher than those in low CD24 expression group;apoptosis genes OPCML, DAPK and TSLC1 mRNA expression were lower than those in low CD24 expression group whereas GRIM-19 mRNA was higher than that in low CD24 expression group. Proliferation genes GBP1 and eIF4E3 mRNA expression in high CD2β expression group were higher than those in low CD2β expression group whereas SCD-1, TLR4 and HERC4 mRNA expression were lower than those in low CD2β expression group;apoptosis genes OPCML, DAPK and TSLC1 mRNA expression were higher than those in low CD2β expression group whereas GRIM-19 mRNA was lower than that in low CD2β expression group.Conclusion: CD24 molecule expression abnormally increases whereas CD2β molecule expression abnormally decreases in cervical cancer tissues, and the specific expression levels can be used to evaluate cervical cancer cell proliferation and apoptosis, indirectly reflect the tumor condition and are expected to become the reference for long-term therapy development.