Objective The current paper aims to investigate the value of 18F-FLT PET in the diagnosis of lung cancer and the monitoring of tumor proliferation. Methods A total of 36 patients received and cured by the General Hospital of Chinese PLA from September 2005 to October 2008 (27 males and 9 females, aged 38 years to 74 years) with chest CT suspected lung cancer were examined with 18F-FLT PET. Up to 42 patients (29 males and 13 females, aged 37 years to 75 years) received and cured at the same time also underwent 18F-FDG PET. The current experimental results were compared with that of the tumor pathology. Immunohistochemistry was used to measure the expression of cell nuclear antigen of excisional disease tissues Ki-67. Results The 18F-FDG PET standardize uptake value (SUV) of lung cancer (SUV, 5. 2+2. 9) was higher than that of the 18F-FLT PET SUV (3. 2±1. 3) (P<0.05). The sensitivity of 18F-FLT PET for the detection of primary lung cancer was 77%, the specificity was 86%, and the accuracy was 78%. The sensitivity, specificity, and accuracy of 18F-FDG PET were 88%, 50%, and 79%, respectively. The sensitivity, specificity, and accuracy for the lymph node staging with 18F-FLT PET were 47%, 88% and 75%, respectively, compared with the 68%, 84%, and 79% for 18F-FDG PET, respectively. 18F-FLT SUV of lung cancer was positively correlated with the Ki-67 index (r=0. 8278, P<0. 001) than that of 18F-FDG SUV (r=0. 0079, P=0. 968). Conclusions I8F-FLT can be made to uptake by specificity of lung cancer tissue, and its uptake value is correlated significantly with the proliferation of lung cancer. Therefore, 18F-FLT PET can be applied to assist the diagnosis of lung tumor, and is expected to be a tool to determine the proliferation activity of tumor cells.%目的 探讨18F-FLT PET在肺癌诊断和肿瘤增殖检测方面的应用价值.方法 对2005年9月-2008年10月解放军总医院收治的36例(男27例,女9例,年龄38～74岁)胸部CT疑似肺癌患者进行18F-FLT PET扫描,对同期收治的42例(男29例,女13例,年龄37～75岁)胸部CT疑似肺癌患者进行18F-FDG PET扫描,并将结果与肿瘤组织病理学结果相对照；采用免疫组化测定切除病变组织细胞核抗原Ki-67的表达情况.结果 肺癌18F-FDG PET的标准化摄取值(SUV)为5.2±2.9,明显高于18F-FLT PET的SUV值(3.2±1.3,P＜0.05).18F-FLT PET诊断肺癌原发病灶的灵敏性、特异性和准确性分别为77％、86％和78％,18F-FDG PET则分别为88％、50％和79％.18F-FLT PET判断肺癌淋巴结分期的敏感性、特异性和准确性分别为47％、88％和75％,18F-FDG PET则分别为68％、84％和79％.肺癌18F-FLT SUV值与Ki-67指数呈显著正相关(r=0.8278,P＜0.001),而18F-TDG SUV值与Ki-67指数无明显相关性(r=0.0079,P=0.968).结论 18F-FLT可被肺癌组织特异性摄取,可用于肺部肿瘤的辅助诊断,并有望成为判断肿瘤细胞增殖活性的工具.
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