目的 研究腹膜后肿瘤手术联合术中放疗的安全性.方法 以2009年7月-2010年7月收治的经腹部CT和(或)MRI确诊为腹膜后肿瘤的患者为研究对象,除外以下病例:(1)术后病理证实肿瘤组织来源于淋巴造血系统、泌尿生殖系统;(2)术前CT和(或)MRI已发现肿瘤病变范围广泛,腹膜后多处受累.保留病变局限于腹膜后单一区域的患者.共筛选出符合入选标准者62例,将其分为两组:联合治疗组(n=30),行腹膜后肿瘤切除联合术中放疗;对照组(n=32),单纯行腹膜后肿瘤切除术.比较两组术前术后白细胞计数变化、胃肠功能恢复时间、切口拆线时间及并发症情况.结果 联合治疗组与对照组在术前术后白细胞计数变化、胃肠功能恢复时间、切口拆线时间及并发症的差异无统计学意义(P>0.05).结论 手术联合术中放疗治疗腹膜后肿瘤安全性好,且不增加术后并发症风险.%Objective To study the safety of tumorectomy combined with intraoperative radiotherapy in the treatment of retroperitoneal tumor. Methods The patients diagnosed as retroperitoneal tumor by abdominal CT and/or MRI since July 2009 to July 2010 were chosen as the objects with the exclusion of the following conditions: 1) pathologically confirmed lymphoma, hematopoietic system tumor, and urogenital system tumor: 2) tumor was found to involve a wide area or with multiple lesions in retroperitoneal space as shown by preoperative CT and/or MRI. Sixty-two patients were found to have localized tumor, and they were divided into two groups:combined treatment group ( n= 30) and control group ( n=32). The patients in combined treatment group underwent total excision of the tumor followed by intraoperative radiotherapy; in control group the patients underwent tumorectomy only. The changes in pre- and post-operative white blood cell count, recovery of gastrointestinal function, wound healing and incidence of complications were compared between the two groups. Results There was no difference between the two groups in pre- and post-operative white blood cell counting,recovery of gastrointestinal function, wound healing and incidence of complications (P＞0.05). Conclusion Tumorectomy combined with intraoparative radiotherapy in the treatment of retroperitoneal tumor is safe and entailing no higher incidence of complications.
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