质谱技术在临床生化检测中的应用

摘要

Recently, mass spectrometry has been playing more and more important roles in clinical laboratory medicine.The development of gas or high-performance liquid chromatography and tandem mass spectrometry technologies has expanded the application of mass spectrometry, and it becomes an efficient tool for clinical biochemical determination.This article introduces the technical principle of mass spectrometry and presents the utilization in clinical biochemistry, such as newborn screening for genetic diseases and so on.Mass spectrometry has shown great potential with the advantages of high specificity, high sensitivity and low limit of determination in clinical biochemistry.%近年来，质谱技术在临床医学检验中所发挥的作用受到越来越多的关注。气相或高效液相色谱－质谱联用技术以及串联质谱技术的发展大大拓展了这项技术的应用范围，使其成为临床生化检验中有效的检测工具。文章对质谱以及生物质谱技术做了简单介绍，对其应用于临床生化检验中的几大项目，如新生儿遗传代谢病筛查等做了介绍。质谱技术较其他传统生化免疫方法具有高特异性、高灵敏性、低检测限等明显优势，其作为一项新技术具有很好的发展前景。