The advances in the research for the quantitative method of alpha fetoprotein ( AFP ) home and abroadly in recent years are reviewed , including immunosensor and isotope dilution mass spectrometry , which are applied on the AFP quantitation and standardization .The absence of absolute quantitative method of AFP is discussed , and the significance of certified reference material , traceability and establishing a standard quantitative method of AFP is described .%综述了近年来国内外甲胎蛋白( AFP)不同定量方法的最新研究进展,包括免疫传感器及同位素稀释质谱法等在AFP定量及标准化研究方面的应用分析及前景展望,讨论了AFP准确定量方法的缺失,阐述了研制AFP标准物质及建立AFP标准检测方法和溯源性的意义。
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