间接法建立生物参考区间

摘要

It is significant for clinical medical laboratories to provide reliable biological reference intervals , which is aimed at guiding proper clinical treatment process .The establishment of biological reference intervals by indirect method which has been arised in recent years has shown great significance in evaluating biological reference intervals periodically within laboratories and establishing biological reference intervals for those projects which cannot be made through direct methods .It is undoubtedly a simple and inexpensive method .This article reviews the basic methods in the process of establishing biological reference intervals by indirect method according to pertinent literatures , which consists of datum acquistion, datum transformation , outlier excluding and reference interval gaining .%医学实验室为临床提供可靠的生物参考区间对正确指导临床诊疗过程有着重要的意义。近年来提出的间接法建立生物参考区间是一种简便、成本低廉的方法，适用于一些无法使用直接法建立生物参考区间的项目和实验室已有检验项目的定期评审。本文基于文献报道，介绍了间接法建立生物参考区间的基本步骤和方法，包括数据采集、数据变换、离群值的剔除和参考区间的取值。