降钙素原对感染性心内膜炎的预后判断价值

摘要

Objective To analyze the significance of serum procalcitonin(PCT)for the prognosis of infective endocarditis(IE). Methods A total of 80 patients with IE were enrolled. IE patients with poor prognosis(severe complications or death)were as poor prognosis group,and IE patients without complications were as no complication group. Serum PCT of the 2 groups were determined by enzyme-linked fluorescence analysis,and C-reactive protein (CRP)was analyzed by nephelometry immunoassay. The levels of PCT and CRP were compared between the 2 groups. The sensitivities,specificities,positive predictive values and negative predictive values of PCT and CRP for judging IE poor prognosis were compared. Results PCT and CRP in poor prognosis group had higher levels and positive rates than those in no complication group(P<0.05). The sensitivity,specificity,positive predictive value and negative predictive value of PCT for IE poor prognosis diagnosis had no statistical significance compared with CRP(P>0.05). Conclusions Monitoring serum PCT is of important significance for the prognosis diagnosis of IE, which should be combined with CRP determination when available.%目的：分析血清降钙素原（PCT）对感染性心内膜炎（IE）的预后判断价值。方法选择80例 IE 患者，将出现不良预后（严重并发症或死亡）的 IE 患者作为 IE 不良预后组，未出现并发症的 IE 患者作为 IE 无并发症组。采用酶联荧光分析法检测2个组患者血清 PCT，免疫比浊法检测 C 反应蛋白(CRP)。将2个组患者的 PCT 和 CRP 水平进行比较，并比较 PCT 与 CRP 判断 IE 不良预后的敏感性、特异性、阳性预测值和阴性预测值。结果 IE 不良预后组 PCT、CRP 水平和阳性率均高于 IE 无并发症组（P<0.05）。PCT 对 IE 不良预后的诊断敏感性、特异性、阳性预测值、阴性预测值与 CRP 相比,差异无统计学意义（P>0.05）。结论实施血清PCT 水平的监测对 IE 的预后判断具有重要的临床价值，有条件时应联合检测 CRP。